Larynx, hypopharynx & trachea

Squamous cell carcinoma

Basaloid squamous cell carcinoma



Topic Completed: 1 November 2013

Minor changes: 2 March 2021

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PubMed Search: Basaloid squamous cell carcinoma larynx

Nat Pernick, M.D.
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Cite this page: Pernick N. Basaloid squamous cell carcinoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/larynxbasaloidscc.html. Accessed December 8th, 2021.
Definition / general
  • Highly malignant, median survival 18 months (for all sites in head and neck)
  • Heavy smokers or drinkers, often with advanced disease at diagnosis and other primary tumors in the area
  • Usually men, ages 50+ years
  • Usually base of tongue, hypopharynx or supraglottic larynx
Case reports
Treatment
  • Radical surgical excision, radical neck dissection and supplemental radiochemotherapy
Gross description
  • Firm to hard, tan-white masses, may have central necrosis and up to 6 cm
Microscopic (histologic) description
  • Typical areas of squamous cell carcinoma (invasive and in situ) with nests or cords of small crowded cells with minimal cytoplasm, hyperchromatic nuclei, comedonecrosis, prominent hyalinization and peripheral palisading, small cystic spaces and mitotic activity
Positive stains
Electron microscopy description
  • Rare tonofilaments, variable desmosomes
Differential diagnosis
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