Larynx, hypopharynx & trachea

Benign tumors / nonneoplastic

Giant cell tumor

Topic Completed: 1 November 2013

Minor changes: 16 March 2021

Copyright: 2002-2021,, Inc.

PubMed Search: Giant cell tumor larynx

Nat Pernick, M.D.
Page views in 2020: 727
Page views in 2021 to date: 778
Cite this page: Pernick N. Giant cell tumor. website. Accessed December 8th, 2021.
Definition / general
  • Rare; < 50 cases reported
  • Benign but can invade into vital structures or cause airway obstruction
  • Usually involves thyroid cartilage in areas of enchondral ossification with extension into adjacent structures
Case reports
  • Excision; no recurrences reported
Microscopic (histologic) description
  • Numerous multinucleated osteoclast-like giant cells within cellular and vascular stroma containing plump, oval mononuclear cells with nuclei similar to giant cells
  • Expansile and infiltrative growth; frequent mitotic figures; often secondary cystic degeneration, reactive bone formation; no cytologic atypia
Differential diagnosis
Additional references
Back to top
Image 01 Image 02