Larynx, hypopharynx & trachea

Benign tumors / nonneoplastic

Giant cell tumor

Last author update: 1 November 2013
Last staff update: 30 June 2022

Copyright: 2002-2023,, Inc.

PubMed Search: Giant cell tumor larynx

Nat Pernick, M.D.
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Cite this page: Pernick N. Giant cell tumor. website. Accessed September 21st, 2023.
Definition / general
  • Rare; < 50 cases reported
  • Benign but can invade into vital structures or cause airway obstruction
  • Usually involves thyroid cartilage in areas of enchondral ossification with extension into adjacent structures
Case reports
  • Excision; no recurrences reported
Microscopic (histologic) description
  • Numerous multinucleated osteoclast-like giant cells within cellular and vascular stroma containing plump, oval mononuclear cells with nuclei similar to giant cells
  • Expansile and infiltrative growth; frequent mitotic figures; often secondary cystic degeneration, reactive bone formation; no cytologic atypia
Differential diagnosis
Additional references
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