Larynx, hypopharynx & trachea



Topic Completed: 1 December 2013

Minor changes: 3 March 2021

Copyright: 2002-2021,, Inc.

PubMed Search: Grossing

Nat Pernick, M.D.
Page views in 2020: 653
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Cite this page: Pernick N. Grossing. website. Accessed December 8th, 2021.
Definition / general
  • Open in midline posteriorly, ink margins, take tissue for special studies
  • Fix specimen
  • Remove hyoid bone and inspect pre-epiglottic tissue
  • Slice larynx (see below) and photograph
  • For supraglottic and hypopharyngeal carcinomas, blocks should include relationship between tumor and anterior resection margin at base of tongue
  • For partial laryngectomy specimens, inferior margin is usually most critical
  • At least one section per 1 cm of tumor for large tumors, including tumor center and periphery and maximum depth of invasion
  • Submit entire tumor if can do so in 5 sections or less
  • Submit resection margins
  • Nonneoplastic mucosa
  • Bone or cartilage that is grossly involved by tumor
  • Thyroid gland if present
  • Lymph nodes
  • Tracheostomy site

  • Glottic tumors: show tumor relationship to ventricle, thyroid cartilage and cricoid cartilage by coronal section (plane dividing body into front and back, coronal section of normal larynx)
  • Epiglottic tumors: determine extent of invasion of preepiglottic space by sagittal sections (plane dividing body into right and left, sagittal section of larynx)
  • Pyriform sinus tumors: show invasion of supraglottic larynx and thyroid lamina by horizontal sections

Additional references
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