Larynx, hypopharynx & trachea

Precursor epithelial lesions

Hyperplasia



Topic Completed: 1 November 2013

Minor changes: 3 March 2021

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed Search: Hyperplasia [title] larynx [title]

Nat Pernick, M.D.
Page views in 2020: 1,367
Page views in 2021 to date: 1,772
Cite this page: Pernick N. Hyperplasia. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/larynxhyperplasia.html. Accessed December 8th, 2021.
Definition / general
  • Also called keratosis
  • Usually involves true vocal cords and interarytenoid area
  • Associated with smokers, singers and others who use voices excessively
Gross description
  • White thickening of involved areas
  • Verrucous keratosis if undulating warty configuration
  • Pachyderma larynges if extensive keratinization
Microscopic (histologic) description
  • When in respiratory (ciliated columnar) epithelium (false cord, ventricle, subglottic region), initially hyperplasia of reserve cells under epithelium, then replacement of epithelium by full thickness reserve cells, then complete squamous metaplasia; may have hyperkeratotic epithelium
  • No nuclear abnormalities are present but underlying submucosal glands persist
  • Pseudoepitheliomatous hyperplasia: exuberant reactive overgrowth of squamous epithelium without atypia; may resemble invasive squamous cell carcinoma
Differential diagnosis
Back to top
Image 01 Image 02