Larynx, hypopharynx & trachea

Squamous cell carcinoma

Lymphoepithelial carcinoma

Last author update: 1 November 2013
Last staff update: 9 May 2020

Copyright: 2002-2023,, Inc.

PubMed Search: Lymphoepithelioma-like carcinoma larynx

Nat Pernick, M.D.
Adriana Handra-Luca, M.D., Ph.D.
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Cite this page: Pernick N, Handra-Luca A. Lymphoepithelial carcinoma. website. Accessed September 26th, 2023.
Definition / general
  • Often men, mean age 64 years
  • Usually p53+ but EBV negative
  • Usually cervical nodal metastases at diagnosis; 1/3 die of disease
  • Often mixed with classic squamous cell carcinoma
Clinical features
  • Trachea:
    • EBV related, nonkeratinized tumor with syncytial sheets of undifferentiated cells with minimal cytoplasm, prominent nucleoli, numerous mitoses and lymphocytes
    • Similar to nasopharyngeal tumor but very rare in trachea
Case reports
  • Resection, radiotherapy
Additional references
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