Larynx, hypopharynx & trachea
Squamous cell carcinoma
Lymphoepithelial carcinoma
Last author update: 1 November 2013
Last staff update: 9 May 2020
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PubMed Search: Lymphoepithelioma-like carcinoma larynx
Table of Contents
Definition / general | Clinical features | Case reports | Treatment | Additional referencesCite this page: Pernick N, Handra-Luca A. Lymphoepithelial carcinoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/larynxlel.html. Accessed September 26th, 2023.
Definition / general
- Often men, mean age 64 years
- Usually p53+ but EBV negative
- Usually cervical nodal metastases at diagnosis; 1/3 die of disease
- Often mixed with classic squamous cell carcinoma
Clinical features
- Trachea:
- EBV related, nonkeratinized tumor with syncytial sheets of undifferentiated cells with minimal cytoplasm, prominent nucleoli, numerous mitoses and lymphocytes
- Similar to nasopharyngeal tumor but very rare in trachea
Case reports
- 22 year old man with dyspnea on exertion (Surg Today 2007;37:584)
- 27 year old woman with EBV+ tumor (Ann Thorac Cardiovasc Surg 2007;13:191)
- Young woman treated with surgery, radiotherapy and chemotherapy (Indian J Cancer 2002;39:112)
Treatment
- Resection, radiotherapy
Additional references
