Larynx, hypopharynx & trachea
Inflammatory / infectious lesions
Mucous membrane plasmacytosis
Last author update: 1 November 2013
Last staff update: 3 March 2021
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PubMed Search: Mucous membrane plasmacytosis larynx
Table of Contents
Definition / general | Clinical features | Treatment | Gross description | Microscopic (histologic) description | Microscopic (histologic) images | Stains | Additional referencesCite this page: Pernick N, Handra-Luca A. Mucous membrane plasmacytosis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/larynxmucousmembraneplasmacytosis.html. Accessed September 26th, 2023.
Definition / general
- For upper aerodigestive tract cases, 67% were men, mean age 54 years, range 40 - 67 years
- Affects larynx, pharynx, palate, lips, mouth, tongue and trachea
Clinical features
- Trachea: nonneoplastic proliferative disorder of plasma cells
Treatment
- Unknown: antibiotics, steroids, surgery are unsuccessful although apparently a benign process
Gross description
- Cobblestone or warty appearance of mucosa of of larynx, pharynx, palate, lips, mouth, tongue, trachea
Microscopic (histologic) description
- Psoriasiform epithelial hyperplasia with dyskeratosis and dense subepithelial plasmacytosis
- Diffuse and expansive but mature plasma cells are polyclonal (i.e. no light chain restriction)
Microscopic (histologic) images
Images hosted on other servers:
Buccal mucosa: hyperplastic, parakeratinized
stratified squamous epithelium with
dense infiltrate of mature
plasma cells in lamina propria
Buccal mucosa: plasma
cells are IgG+, CD138+,
both kappa+ and lambda+
Stains
- Polyclonal light chains
Additional references
