Larynx, hypopharynx & trachea
Inflammatory / infectious lesions
Mucous membrane plasmacytosis

Topic Completed: 1 November 2013

Minor changes: 26 November 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Mucous membrane plasmacytosis larynx

Nat Pernick, M.D.
Adriana Handra-Luca, M.D.
Page views in 2019: 152
Page views in 2020 to date: 142
Cite this page: Pernick N, Handra-Luca A. Mucous membrane plasmacytosis. website. Accessed August 6th, 2020.
Definition / general
  • For upper aerodigestive tract cases, 2/3 were men, mean age 54 years, range 40 - 67 years
  • Affects larynx, pharynx, palate, lips, mouth, tongue and trachea
Clinical features
  • Trachea: nonneoplastic proliferative disorder of plasma cells
  • Unknown: antibiotics, steroids, surgery are unsuccessful although apparently a benign process
Gross description
  • Cobblestone or warty appearance of mucosa of of larynx, pharynx, palate, lips, mouth, tongue, trachea
Microscopic (histologic) description
  • Psoriasiform epithelial hyperplasia with dyskeratosis and dense subepithelial plasmacytosis
  • Diffuse and expansive but mature plasma cells are polyclonal (i.e. no light chain restriction)
Microscopic (histologic) images

Images hosted on other servers:

Buccal mucosa: hyperplastic, parakeratinized
stratified squamous epithelium with
dense infiltrate of mature
plasma cells in lamina propria

Buccal mucosa: plasma
cells are IgG+, CD138+,
both kappa+ and lambda+

  • Polyclonal light chains
Additional references
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