Bone marrow neoplastic
Bone marrow - neoplastic myeloid
General
WHO-HAEM5 and ICC comparison - AML
Author: Syed Zaidi, M.D.
Last author update: 1 December 2011
Last staff update: 27 April 2023 (update in progress)
Copyright: 2001-2023, PathologyOutlines.com, Inc.
PubMed Search: AML [title] Classification [title]
Cite this page: Zaidi S. WHO-HAEM5 and ICC comparison - AML. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/leukemiaAMLclass.html. Accessed June 6th, 2023.
Definition / general
- French American British (FAB) classification system was used from 1976 to 2001, divided AML into M0 - M7 (Br J Haematol 1976;33:451)
- WHO classification (2001 and revised in 2008) requires minimium of 20% of blasts in bone marrow or blood to diagnose AML (was 30% under FAB); eliminates myelodysplastic category of "refractory anemia with excess blasts in transformation" (Blood 2002;100:2292)
- WHO classification also separates out AML "with recurrent genetic abnormalities" which have distinct clinical features
Acute myeloid leukemias with recurrent genetic abnormalities:
- AML with t(8;21)(q22;q22); RUNX1-RUNX1T1
- AML with inv(16)(p13.1;q22) or t(16;16)(p13.1;q22); CBF&beta-MYH11
- Acute promyelocytic leukemia with t(15;17)(q22;q12); PML/RAR&alpha and variants
- AML with t(9;11)(p22;q23); MLLT3-MLL
- AML with t(6;9)(p23;q34); DEK-NUP214
- AML with inv(3)(q21q26.2) or t(3;3)(q21;q26.2); RPN1-EVI1
- AML (megakaryoblastic) with t(1;22)(p13;q13); RBM15-MKL1
- AML with mutated NPM1*
- AML with mutated CEBPA*
* provisional
Acute myeloid leukemia with myelodysplasia related changes
Therapy related acute myeloid leukemia
- Alkylating agent related
- Topoisomerase II inhibitor related (some maybe lymphoid)
Acute myeloid leukemia not otherwise categorized:
- AML minimally differentiated (M0)
- AML without maturation (M1)
- AML with maturation (M2)
- Acute myelomonocytic leukemia (M4)
- Acute monoblastic and monocytic leukemia (M5a, M5b)
- Acute erythroid leukemia (M6)
- Acute megakaryoblastic leukemia (M7)
- Acute basophilic leukemia
- Acute panmyelosis with myelofibrosis
Myeloid Sarcoma
Myeloid proliferations related to Down syndrome:
- Transient abnormal myelopoeisis
- Myeloid leukemia associated with Down syndrome
Blastic plasmacytoid dentritic cell neoplasm
Acute leukemia of ambiguous lineage:
- Acute undifferentiated leukemia
- Mixed phenotype acute leukemia with t(9;22)(q34;q11.2); BCR-ABL1
- Mixed phenotype acute leukemia with t(v;11q23); MLL rearranged
- Mixed phenotype acute leukemia, B/myeloid, NOS
- Mixed phenotype acute leukemia, T/myeloid, NOS
- Mixed phenotype acute leukemia, NOS, rare types
- Other acute leukemia of ambiguous lineage
