Bone marrow neoplastic

Bone marrow - neoplastic myeloid


WHO-HAEM5 and ICC comparison - AML

Last author update: 1 December 2011
Last staff update: 27 April 2023 (update in progress)

Copyright: 2001-2023,, Inc.

PubMed Search: AML [title] Classification [title]

Syed Zaidi, M.D.
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Cite this page: Zaidi S. WHO-HAEM5 and ICC comparison - AML. website. Accessed June 6th, 2023.
Definition / general
  • French American British (FAB) classification system was used from 1976 to 2001, divided AML into M0 - M7 (Br J Haematol 1976;33:451)
  • WHO classification (2001 and revised in 2008) requires minimium of 20% of blasts in bone marrow or blood to diagnose AML (was 30% under FAB); eliminates myelodysplastic category of "refractory anemia with excess blasts in transformation" (Blood 2002;100:2292)
  • WHO classification also separates out AML "with recurrent genetic abnormalities" which have distinct clinical features

Acute myeloid leukemias with recurrent genetic abnormalities:
  • AML with t(8;21)(q22;q22); RUNX1-RUNX1T1
  • AML with inv(16)(p13.1;q22) or t(16;16)(p13.1;q22); CBF&beta-MYH11
  • Acute promyelocytic leukemia with t(15;17)(q22;q12); PML/RAR&alpha and variants
  • AML with t(9;11)(p22;q23); MLLT3-MLL
  • AML with t(6;9)(p23;q34); DEK-NUP214
  • AML with inv(3)(q21q26.2) or t(3;3)(q21;q26.2); RPN1-EVI1
  • AML (megakaryoblastic) with t(1;22)(p13;q13); RBM15-MKL1
  • AML with mutated NPM1*
  • AML with mutated CEBPA*

* provisional

Acute myeloid leukemia with myelodysplasia related changes

Therapy related acute myeloid leukemia
  • Alkylating agent related
  • Topoisomerase II inhibitor related (some maybe lymphoid)

Acute myeloid leukemia not otherwise categorized:
  • AML minimally differentiated (M0)
  • AML without maturation (M1)
  • AML with maturation (M2)
  • Acute myelomonocytic leukemia (M4)
  • Acute monoblastic and monocytic leukemia (M5a, M5b)
  • Acute erythroid leukemia (M6)
  • Acute megakaryoblastic leukemia (M7)
  • Acute basophilic leukemia
  • Acute panmyelosis with myelofibrosis

Myeloid Sarcoma

Myeloid proliferations related to Down syndrome:
  • Transient abnormal myelopoeisis
  • Myeloid leukemia associated with Down syndrome

Blastic plasmacytoid dentritic cell neoplasm

Acute leukemia of ambiguous lineage:
  • Acute undifferentiated leukemia
  • Mixed phenotype acute leukemia with t(9;22)(q34;q11.2); BCR-ABL1
  • Mixed phenotype acute leukemia with t(v;11q23); MLL rearranged
  • Mixed phenotype acute leukemia, B/myeloid, NOS
  • Mixed phenotype acute leukemia, T/myeloid, NOS
  • Mixed phenotype acute leukemia, NOS, rare types
  • Other acute leukemia of ambiguous lineage
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