Bone marrow neoplastic

Bone marrow - neoplastic myeloid

AML not otherwise specified

AML M5



Last author update: 1 February 2013
Last staff update: 19 September 2022 (update in progress)

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PubMed Search: Acute monoblastic and acute monocytic leukemia AML M5

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Cite this page: Mihova D. AML M5. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/leukemiaacutemonocyticleukemia.html. Accessed February 4th, 2023.
Definition / general
Diagnosis
  • 80% or more nonerythroid bone marrow cells are monocyte lineage (monoblasts, promonocytes and monocytes)
  • A minor neutrophil component < 20%
Enzyme cytochemistry
  • Monoblast granules and monocytes are strongly positive for nonspecific esterase and lysozyme, but negative for myeloperoxidase
  • More mature monocyte lineage cells may be weakly myeloperoxidase positive
  • Note: if NSE negative, confirm monocyte lineage with immunostains
Positive stains
Molecular / cytogenetics description
  • 11q23 translocations in 19%, trisomy 8 in 17%
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