Bone marrow neoplastic

Bone marrow - neoplastic myeloid

AML not otherwise specified

AML hypocellular

Topic Completed: 1 February 2013

Minor changes: 18 June 2020

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PubMed Search: Hypocellular AML

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Cite this page: Mihova D. AML hypocellular. website. Accessed January 28th, 2022.
Definition / general
  • Defined as < 20% bone marrow cellularity, 20% or more are blasts (WHO); other definitions range up to 40% cellularity
  • Up to 10% of AML cases
  • Median age 67 years (Leuk Res 1996;20:563)
  • Rare blasts in peripheral blood
  • Often has smoldering course although intensive chemotherapy may cause complete remission
Case reports
Microscopic (histologic) images
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Markedly hypocellular marrow
in 57 year old man with
severe pancytopenia and
rare blasts in blood

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Cells in interstitium are
predominantly blasts

Positive stains
Differential diagnosis
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