Bone marrow neoplastic

Bone marrow - plasma cell and lymphoid neoplasms

B lymphoblastic leukemia / lymphoma with recurrent genetic abnormalities

t(9;22)(q34;q11); BCR::ABL1



Last author update: 1 March 2013
Last staff update: 29 September 2023

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PubMed Search: B lymphoblastic leukemia lymphoma with t(9;22)(q34;q11); BCR-ABL1

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Cite this page: Mihova D. t(9;22)(q34;q11); BCR::ABL1. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/leukemiapreBt922.html. Accessed May 19th, 2024.
Definition / general
  • ALL with BCR-ABL1 fusion transcript (Philadelphia chromosome)
  • 30% of adults with ALL, 4% of children but 80% of infants
  • Excluding infants, older age and higher WBC at presentation than other B ALL
  • May have more organomegaly or CNS involvement than other B ALL
  • Poor prognosis
Treatment
Microscopic (histologic) description
  • No defining morphology, but large blasts with prominent nucleoli and cytoplasmic granules are more common than other B ALL
Microscopic (histologic) images

AFIP images
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Leukemic cells resemble early erythroblasts

Cytology images

Contributed by Julia Braza, M.D., M.S.
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CSF

Positive stains
Flow cytometry images

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B-ALL associated with t(9;22); lymphoblasts express B-lineage
markers CD19, CD20, CD22, immature markers CD34, TdT, CD10,
and aberrant CD25; they are aberrantly dim for CD38 and CD81;
this pattern is useful in identifying minimal residual disease

Molecular / cytogenetics description
  • Translocation involves abl on #9q34 (tyrosine kinase) and bcr on #22q11 (breakpoint cluster region)
  • Most childhood cases associated with p190 kd BCR-ABL1 fusion protein
  • In 50% of adults, has p210 kd fusion protein that is present in CML, the rest is p190 kd; no definitive clinical difference
Molecular / cytogenetics images

Contributed by Julia Braza, M.D., M.S. and AFIP
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FISH

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Karyotype



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Drawing of translocation

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