Bone marrow neoplastic

Bone marrow - plasma cell and lymphoid neoplasms

B lymphoblastic leukemia/lymphoma with recurrent genetic abnormalities

t(5;14)(q31;q32); IGH / IL3



Topic Completed: 1 February 2013

Minor changes: 16 December 2021

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PubMed Search: B lymphoblastic leukemia IL3-IGH

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Cite this page: Mihova D. t(5;14)(q31;q32); IGH / IL3. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/leukemiat514.html. Accessed January 19th, 2022.
Definition / general
  • Diagnosis based on immunophenotype and genetic findings, even with low blast count
  • Very rare; < 1% of all ALL; both children and adults (Blood 1989;73:2081)
  • Presents with variable eosinophilia; may be asymptomatic and lack any blasts (Medicine (Baltimore) 1990;69:232)
Case reports
Microscopic (histologic) description
  • CD19+ CD10+ lymphoblasts with circulating reactive eosinophils
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