Liver & intrahepatic bile ducts

Benign / nonneoplastic

Extramedullary hematopoiesis

Topic Completed: 1 August 2012

Minor changes: 11 June 2021

Copyright: 2002-2021,, Inc.

PubMed Search: Extramedullary hematopoiesis[TI] liver

Shilpa Jain, M.D.
Page views in 2020: 2,589
Page views in 2021 to date: 3,419
Cite this page: Jain S. Extramedullary hematopoiesis. website. Accessed December 6th, 2021.
Definition / general
  • Usually discovered incidentally or associated with anemia
  • Rarely presents as liver mass
  • Only very few liver nodules of EMH have been described in the literature (Diagn Cytopathol 1997;16:51)
Case reports
  • Radiation or hydroxyurea if symptomatic
Microscopic (histologic) description
  • Erythroid precursors in sinusoids (resemble lymphocytes), myeloid precursors in portal tracts (resemble mixed portal infiltrate or eosinophils in neonates)
  • Also megakaryocytes within sinuses
Microscopic (histologic) images

Contributed by Dr. S. Rajendiran

50 year old man with vague abdominal pain; CT abdomen showed a 2 cm mass; CT guided biopsy performed

Contributed by Dr. Nikhil Sangle and ARUP Laboratories

Liver with extramedullary hematopoiesis

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H&E and CD68

Differential diagnosis
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