Liver & intrahepatic bile ducts
Benign / nonneoplastic
Biliary adenofibroma

Topic Completed: 1 February 2012

Minor changes: 1 August 2020

Revised: 24 January 2019, last major update February 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Biliary adenofibroma

Deepali Jain, M.D.
Page views in 2019: 829
Page views in 2020 to date: 593
Cite this page: Jain D. Biliary adenofibroma. website. Accessed August 6th, 2020.
Definition / general
  • Extremely rare (< 25 reported cases) large solid cystic mass
  • Age ranges from 21 - 79 years; no gender predilection
  • Monosomy 22 in one case (Cancer Genet Cytogenet 1997;93:183)
  • Appears to originate from interlobular or larger bile ducts
  • Benign behavior to date but may be premalignant
Case reports
Microscopic (histologic) description
  • Microcystic and tubular structures lined by low columnar / cuboidal epithelium
  • Luminal eosinophilic material, red blood cells, bile and dense fibrous stroma with spindle cells displaying mild nuclear pleomorphism; no / rare mitotic figures, no stromal invasion
Microscopic (histologic) images

Images hosted on other servers:

Various images

Positive stains
Negative stains
Differential diagnosis
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