Liver & intrahepatic bile ducts

Benign / nonneoplastic

Biliary adenofibroma

Topic Completed: 1 February 2012

Minor changes: 11 June 2021

Copyright: 2002-2021,, Inc.

PubMed Search: Biliary adenofibroma

Deepali Jain, M.D.
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Cite this page: Jain D. Biliary adenofibroma. website. Accessed December 4th, 2021.
Definition / general
  • Extremely rare (< 25 reported cases) large solid cystic mass
  • Age ranges from 21 - 79 years; no gender predilection
  • Monosomy 22 in one case (Cancer Genet Cytogenet 1997;93:183)
  • Appears to originate from interlobular or larger bile ducts
  • Benign behavior to date but may be premalignant
Case reports
Microscopic (histologic) description
  • Microcystic and tubular structures lined by low columnar / cuboidal epithelium
  • Luminal eosinophilic material, red blood cells, bile and dense fibrous stroma with spindle cells displaying mild nuclear pleomorphism; no / rare mitotic figures, no stromal invasion
Microscopic (histologic) images

Images hosted on other servers:

Various images

Positive stains
Negative stains
Differential diagnosis
  • Benign cystic mesothelioma
  • Bile duct adenoma: incidental, small
  • Biliary cyst
  • Biliary cystadenoma: larger, multiloculated cysts, mucinous epithelium with ovarian type of stroma
  • Von Meyenburg complex: smaller, usually multifocal but similar staining pattern
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