Liver & intrahepatic bile ducts
Benign / nonneoplastic
Biliary adenofibroma
Author: Deepali Jain, M.D.
Topic Completed: 1 February 2012
Minor changes: 1 August 2020
Revised: 24 January 2019, last major update February 2012
Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.
PubMed Search: Biliary adenofibroma
Table of Contents
Definition / general | Case reports | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Negative stains | Differential diagnosisCite this page: Jain D. Biliary adenofibroma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/livertumorbiliaryadenofibroma.html. Accessed August 6th, 2020.
Definition / general
- Extremely rare (< 25 reported cases) large solid cystic mass
- Age ranges from 21 - 79 years; no gender predilection
- Monosomy 22 in one case (Cancer Genet Cytogenet 1997;93:183)
- Appears to originate from interlobular or larger bile ducts
- Benign behavior to date but may be premalignant
Case reports
- 47 year old woman (Am J Surg Pathol 2003;27:693)
- 79 year old man (Patholog Res Int 2010;2010:504584)
Microscopic (histologic) description
- Microcystic and tubular structures lined by low columnar / cuboidal epithelium
- Luminal eosinophilic material, red blood cells, bile and dense fibrous stroma with spindle cells displaying mild nuclear pleomorphism; no / rare mitotic figures, no stromal invasion
Microscopic (histologic) images
Images hosted on other servers:
Various images
Negative stains
Differential diagnosis
- Benign cystic mesothelioma
- Bile duct adenoma: incidental, small
- Biliary cyst
- Biliary cystadenoma: larger, multiloculated cysts, mucinous epithelium with ovarian type of stroma
- Von Meyenburg complex: smaller, usually multifocal but similar staining pattern
