Liver & intrahepatic bile ducts
Other malignancies
Hepatoblastoma-mixed epithelial mesenchymal type


Topic Completed: 1 February 2012

Minor changes: 18 March 2021

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PubMed Search: Hepatoblastoma mixed epithelial mesenchymal

Deepali Jain, M.D.
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Cite this page: Jain D. Hepatoblastoma-mixed epithelial mesenchymal type. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/livertumorhepatoblastomamixed.html. Accessed June 20th, 2021.
Definition / general
  • 44% of hepatoblastomas are mixed epithelial mesenchymal type
  • Mixture of fetal / epithelial and mesenchymal cell types
  • Teratoid (34%) or not (10%)
  • Mesenchymal component has spindle oval cells with minimal cytoplasm, frequent osteoid, fibrous septa, myxoid zones, hemorrhage and necrosis
  • Teratoid features are keratinized squamous epithelium, intestinal epithelial, skeletal muscle, mature bone and cartilage, melanin and neuroectodermal structures
Microscopic (histologic) images

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Mixed pattern

Postchemotherapy treatment effect

Positive stains
Negative stains
Electron microscopy description
  • Immature hepatocytes
Molecular / cytogenetics description
Differential diagnosis
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