Table of ContentsDefinition / general | Essential features | Terminology | Clinical features | Radiology description | Gross description | Microscopic (histologic) description | Microscopic (histologic) images | Sample pathology report | Differential diagnosis | Board review style question #1 | Board review style answer #1
Cite this page: Assarzadegan N, Gonzalez RS. Large regenerative nodule. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/livertumorlargeregenerativenodule.html. Accessed November 27th, 2021.
Definition / general
- Low grade regenerative hepatocellular nodule that often arises in the setting of flow abnormalities
- Low malignant potential
- Also known as benign regenerative nodule
- Predominantly isointense or hypointense relative to background liver on T2 weighted images
- Multiple, well circumscribed, round lesions
- Typically 0.5 - 4.0 cm
Microscopic (histologic) description
- Nodules of hyperplastic hepatocytes arranged in thickened hepatic plates
- No distinctive cytoarchitectural features (J Hepatol 2003;39:208)
- Entrapped portal tracts often present
- Surrounding parenchyma shows atrophy and congestion and may undergo fibrosis
Microscopic (histologic) images
Sample pathology report
- Liver, native, orthotopic transplantation:
- Liver parenchyma with bridging fibrosis, prominent sinusoidal dilation and focal large regenerative nodules (see comment)
- Negative for malignancy.
- Margins of resection unremarkable.
- Comment: The findings are consistent with the patient’s reported history of congestive heart failure. The simultaneously explanted heart will be reported separately. A trichrome stain shows bridging fibrosis, focally approaching early cirrhosis. An iron stain is unremarkable.
Board review style question #1
Large regenerative nodules of the liver often arise in the setting of
- Biliary injury
- Chronic viral hepatitis
- Vascular flow abnormalities