Lung nontumor
Infectious
Aspergillus


Topic Completed: 1 August 2011

Minor changes: 22 July 2020

Copyright: 2003-2020, PathologyOutlines.com, Inc.

PubMed search: aspergillus [title] lung infection

Elliot Weisenberg, M.D.
Page views in 2019: 12,720
Page views in 2020 to date: 7,306
Cite this page: Weisenberg E. Aspergillus. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/lungnontumoraspergillosis.html. Accessed August 13th, 2020.
Definition / general
Clinical features
  • Aspergillus infection is associated with solid organ or bone marrow transplants and antileukemic chemotherapy; relatively uncommon in AIDS patients
  • Allergic bronchopulmonary aspergillosis: bronchocentric granulomas in asthmatics that contain numerous eosinophils and noninvasive aspergillus organisms or other fungi (Clin Dev Immunol 2011;2011:843763); patients have elevated IgE directed against aspergillus antigens, also thick mucus plugs; impacted mucus may form cast of airways (plastic bronchitis); over time, bronchi become dilated, causing bronchiectasis; patients develop intractable bronchospasm; rarely other fungi cause similar disease
  • Bronchocentric granulomatosis: cell mediated reaction to aspergillus in airway; circumferential granulomatous inflammation surrounding small airways with mucus and cellular debris and loss of lining epithelium within airway (Radiographics 2007;27:617); may be isolated or part of allergic bronchopulmonary aspergillosis; rarely due to other fungi
  • References: J Bras Pneumol 2009;35:1238
Diagrams / tables

Images hosted on other servers:
Invasive aspergillosis by Aspergillus fumigatus Invasive aspergillosis by Aspergillus fumigatus Invasive aspergillosis by Aspergillus fumigatus

Invasive aspergillosis by Aspergillus fumigatus

Gross description
  • Invasive disease usually shows targetoid lesions with peripheral consolidation and central thrombosed vessels due to angioinvasive fungi; variable bronchopneumonia or lobar pneumonia
Gross images

Images hosted on other servers:
Abscess

Abscess

Aspergilloma Aspergilloma

Aspergilloma

Microscopic (histologic) description
  • Dichotomous (into two nearly equal branches, or 45 degrees) branching, hyphae with frequent septation, diameter ranges from 2.5 to 4.5 μm
  • May see aspergillus fruiting body (other fungi may mimic aspergillus, in general, should not definitively diagnose aspergillosis in tissue without the presence of a fruiting body), and often invades vessels
Microscopic (histologic) images

Contributed by Professor Venna Maheshwar, Dr. Kiran Alam, Dr. Anshu Jain and Dr. Claudia Mendez
PAS stains PAS stains

PAS stains

Aspergilloma

Aspergilloma

PAS stains PAS stains

PAS stains

GMS stain

GMS stain



Images hosted on other servers:
Fungus ball

Fungus ball

Hyphae Hyphae

Hyphae

Bronchocentric granulomatosis in asthma patient Bronchocentric granulomatosis in asthma patient

Bronchocentric granulomatosis in asthma patient

Phialoconidia of Aspergillus fumigatus

Phialoconidia of Aspergillus fumigatus


PAS stain

PAS stain

Cytology images

Images hosted on other servers:
Allergic bronchopulmonary aspergillosis with coexistant aspergilloma

Allergic bronchopulmonary
aspergillosis with
coexistant aspergilloma

Invasive aspergillus tracheobronchitis: abundant necrotic material with multiple mycelia, consisting of septate hyphae branching at 45 degrees

Invasive aspergillus tracheobronchitis:
abundant necrotic material with
multiple mycelia, consisting of septate
hyphae branching at 45 degrees

Back to top