Noninfectious granulomatous inflammation

Bronchocentric granulomatosis

Topic Completed: 1 September 2011

Minor changes: 18 March 2021

Copyright: 2003-2021,, Inc.

PubMed search: bronchocentric granulomatosis

Elliot Weisenberg, M.D.
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Cite this page: Weisenberg E. Bronchocentric granulomatosis. website. Accessed October 28th, 2021.
Definition / general
  • Granulomatous disease of lungs in which almost all granulomas are centered in bronchi or bronchioles causing their destruction
  • Immunologic reaction related to chronic eosinophilic pneumonia and allergic bronchopulmonary aspergillosis
  • A histologic pattern of disease, not a specific diagnosis
  • Usually adults, often with asthma history and limited to lungs, may be asymptomatic
  • Usually solitary lesions that appear on chest Xray as atelectasis or consolidation, not nodules
  • Generally favorable prognosis
Gross description
  • Viscous material in involved bronchi
Microscopic (histologic) description
  • Large and medium bronchi infiltrated by neutrophils, eosinophils and necrotic debris surrounded by foreign body giant cells
  • Fragmented elastic tissue (with elastic stain)
  • Also bronchiolitis obliterans
  • No fibrinoid necrosis of vessels
Differential diagnosis
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