Other interstitial pneumonitis / fibrosis

Honeycomb lung

Topic Completed: 1 September 2011

Minor changes: 11 August 2020

Copyright: 2003-2021,, Inc.

PubMed search: honeycomb lung [title]

Elliot Weisenberg, M.D.
Page views in 2020: 1,393
Page views in 2021 to date: 840
Cite this page: Weisenberg E. Honeycomb lung. website. Accessed October 16th, 2021.
Definition / general
  • Final common pathway of various processes causing chronic interstitial fibrosis
  • Progressive shortness of breath, severe interstitial fibrosis, diffuse cystic changes with blebs and subsequent pneumothorax and shrunken lungs (restrictive lung disease) with elevation of diaphragm
Gross description
  • Stiff, spongy and fibrotic lungs with cystic changes
Gross images

Images hosted on other servers:
Honeycomb lung

Honeycomb lung

Microscopic (histologic) description
  • Dense interstitial and peribronchial fibrosis and smooth muscle
  • Reduced alveolar capillaries
  • Marked medial hyperplasia of pulmonary arteries and arterioles
  • Cystically dilated alveoli
  • May have mucinous metaplasia of lining epithelium with atypia
Back to top
Image 01 Image 02