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Definition / general | Gross description | Gross images | Microscopic (histologic) descriptionCite this page: Weisenberg E. Honeycomb lung. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/lungnontumorhoneycomb.html. Accessed January 24th, 2021.
Definition / general
- Final common pathway of various processes causing chronic interstitial fibrosis
- Progressive shortness of breath, severe interstitial fibrosis, diffuse cystic changes with blebs and subsequent pneumothorax and shrunken lungs (restrictive lung disease) with elevation of diaphragm
Gross description
- Stiff, spongy and fibrotic lungs with cystic changes
Microscopic (histologic) description
- Dense interstitial and peribronchial fibrosis and smooth muscle
- Reduced alveolar capillaries
- Marked medial hyperplasia of pulmonary arteries and arterioles
- Cystically dilated alveoli
- May have mucinous metaplasia of lining epithelium with atypia