Lung
Noninfectious granulomatous inflammation
Hyalinizing granuloma
Author: Elliot Weisenberg, M.D.
Last author update: 1 September 2011
Last staff update: 7 August 2020
Copyright: 2003-2023, PathologyOutlines.com, Inc.
PubMed search: hyalinizing granuloma
Table of Contents
Definition / general | Microscopic (histologic) description | Negative stains | Differential diagnosisCite this page: Weisenberg E. Hyalinizing granuloma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/lungnontumorhyalinizinggran.html. Accessed June 10th, 2023.
Definition / general
- Rare, nodular lung lesion
- Usually multiple, bilateral and cause unknown
- Inflammatory reaction of unknown stimulus
- Patients often have a history of autoimmune disease, exposure to fungal or mycobacterial antigens
- Associated with sclerosing mediastinitis, retroperitoneal fibrosis and lymphoma
- May be progressive, but does not cause death
Microscopic (histologic) description
- Central keloid-like collagen, arranged in whorls, surrounded by foreign body giant cells simulating nodular amyloidosis
- May have plasma cells and lymphocytes between collagenous bands
- Usually no epithelioid granulomas, no necrosis
Negative stains
Differential diagnosis
- Amyloidosis (localized), rheumatoid arthritis, silicosis
- Also infection, foreign body granuloma
