Noninfectious granulomatous inflammation

Hyalinizing granuloma

Topic Completed: 1 September 2011

Minor changes: 7 August 2020

Copyright: 2003-2021,, Inc.

PubMed search: hyalinizing granuloma

Elliot Weisenberg, M.D.
Page views in 2020: 1,687
Page views in 2021 to date: 1,471
Cite this page: Weisenberg E. Hyalinizing granuloma. website. Accessed October 25th, 2021.
Definition / general
  • Rare, nodular lung lesion
  • Usually multiple, bilateral and cause unknown
  • Inflammatory reaction of unknown stimulus
  • Patients often have a history of autoimmune disease, exposure to fungal or mycobacterial antigens
  • Associated with sclerosing mediastinitis, retroperitoneal fibrosis and lymphoma
  • May be progressive, but does not cause death
Microscopic (histologic) description
  • Central keloid-like collagen, arranged in whorls, surrounded by foreign body giant cells simulating nodular amyloidosis
  • May have plasma cells and lymphocytes between collagenous bands
  • Usually no epithelioid granulomas, no necrosis
Negative stains
Differential diagnosis
Back to top
Image 01 Image 02