Noninfectious granulomatous inflammation

Hyalinizing granuloma

Last author update: 1 September 2011
Last staff update: 7 August 2020

Copyright: 2003-2023,, Inc.

PubMed search: hyalinizing granuloma

Elliot Weisenberg, M.D.
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Cite this page: Weisenberg E. Hyalinizing granuloma. website. Accessed June 10th, 2023.
Definition / general
  • Rare, nodular lung lesion
  • Usually multiple, bilateral and cause unknown
  • Inflammatory reaction of unknown stimulus
  • Patients often have a history of autoimmune disease, exposure to fungal or mycobacterial antigens
  • Associated with sclerosing mediastinitis, retroperitoneal fibrosis and lymphoma
  • May be progressive, but does not cause death
Microscopic (histologic) description
  • Central keloid-like collagen, arranged in whorls, surrounded by foreign body giant cells simulating nodular amyloidosis
  • May have plasma cells and lymphocytes between collagenous bands
  • Usually no epithelioid granulomas, no necrosis
Negative stains
Differential diagnosis
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