Other nonneoplastic disease

Pulmonary edema

Topic Completed: 1 December 2011

Minor changes: 24 August 2020

Copyright: 2003-2021,, Inc.

PubMed search: pulmonary edema [title] lung

Elliot Weisenberg, M.D.
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Page views in 2021 to date: 3,268
Table of Contents
Clinical features
Cite this page: Weisenberg E. Pulmonary edema. website. Accessed October 27th, 2021.
Clinical features
  • Due to hemodynamic disturbances (cardiogenic) or local microvascular injury

Hemodynamic disturbances:
  • Due to increased hydrostatic pressure from congestive heart failure
  • Lungs are wet and heavy, fluid initially at base of lower lobes because hydrostatic pressure is greater here
  • Congestion, fluid and hemosiderin laden macrophages (heart failure cells) are present
  • Later fibrosis and thickening of alveolar walls (brown induration of lung)

Local microvascular injury:
  • Injury causes leakage of fluids and proteins into interstitial space, eventually into alveoli
  • When diffuse, contributes to acute respiratory distress syndrome
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