Lung tumor

Topic Completed: 1 September 2012

Minor changes: 4 July 2020

Copyright: 2003-2019,, Inc.

PubMed Search: fetal adenocarcinoma lung

Deepali Jain, M.D.
Page views in 2019: 2,004
Page views in 2020 to date: 1,129
Cite this page: Jain D. Fetal. website. Accessed August 10th, 2020.
Definition / general
  • Rare tumor resembling fetal lung in pseudoglandular stage
  • Either high grade or low grade
  • May be a variant of pulmonary blastoma without malignant mesenchymal components
  • Low grade tumors associated with upregulation of Wnt signaling pathway (Mod Pathol 2002;15:617)
  • High grade variant is very aggressive
Microscopic (histologic) description
  • Irregular tubular structures of columnar epithelial cells with clear cytoplasm and oval nuclei, optically clear nuclei rich in biotin
  • Resembles fetal lung in pseudoglandular stage
  • High grade: disorganized glands, large vesicular nuclei, prominent nucleoli, pronounced anisonucleosis, transition to conventional adenocarcinoma, broad areas of necrosis, desmoplastic stroma, p53+, AFP+, no morules (Am J Surg Pathol 1998;22:399)
Microscopic (histologic) images

Images hosted on other servers:

Well differentiated tumor

Cytology description
  • Low grade tumors: subnuclear vacuoles with tigroid features, small, uniform, round nuclei, morules, neuroendocrine differentiation in glandular epithelial cells (Am J Clin Pathol 2010;134:894)
Cytology images

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Various images

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