Lung
Lymphohistiocytic tumors
Diffuse large B cell lymphoma
Author: Deepali Jain, M.D.
Last author update: 1 September 2012
Last staff update: 24 August 2020
Copyright: 2003-2023, PathologyOutlines.com, Inc.
PubMed Search: diffuse large B cell lymphoma lung
Table of Contents
Definition / general | Microscopic (histologic) description | Positive stains | Negative stainsCite this page: Jain D. Diffuse large B cell lymphoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/lungtumordiffuselargecell.html. Accessed May 30th, 2023.
Definition / general
- Presents as large parenchymal mass accompanied by necrosis, occasionally by intrabronchial mass
- May evolve from MALT lymphoma or arise without preexisting lesions
- 5 year survival is 50%
Microscopic (histologic) description
- Pleomorphic large lymphoid cells, usually non-cleaved
- Various patterns of infiltration (Am J Clin Pathol 2004;121:718)
Positive stains
- CD20
Negative stains
- CD3, CD5, CD26
