Lung

Mesenchymal tumors

Leiomyoma



Topic Completed: 1 October 2015

Minor changes: 24 December 2020

Copyright: 2003-2021, PathologyOutlines.com, Inc.

PubMed Search: Leiomyoma [title] lung

Roseann Wu, M.D., M.P.H.
Page views in 2020: 718
Page views in 2021 to date: 709
Cite this page: Wu R. Leiomyoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/lungtumorleiomyoma.html. Accessed October 25th, 2021.
Definition / general
Terminology
  • Primary leiomyoma of lung
Epidemiology
  • Predominantly female, most commonly in 30s - 40s
  • ~2% of benign lung tumors
Sites
Pathophysiology
  • Solitary, benign
Etiology
  • Arises from smooth muscle of bronchial tree or pulmonary vasculature
Clinical features
  • Typically incidental and asymptomatic
  • May present with chest pain, cough, fever, hemoptysis, shortness of breath, pneumonia due to obstruction
Diagnosis
  • Biopsy or resection
Radiology description
  • Round or oval, well defined borders
  • Endobronchial lesions may show pneumonia or atelectasis due to obstruction
Prognostic factors
  • Prognosis and survival excellent
Case reports
Treatment
  • Resection is curative
Clinical images

Images hosted on other servers:
Bronchoscopy

Bronchoscopy

White, smooth ovoid lesion

White, smooth ovoid lesion

Gross description
  • Endobronchial lesion may be attached by a broad stalk
  • Firm, white, well circumscribed nodule
Gross images

Images hosted on other servers:
Bronchoscopic resection

Bronchoscopic resection

Microscopic (histologic) description
  • Bland proliferation of intersecting and whorled smooth muscle fascicles
  • Fusiform spindle cells with no atypia, no hypercellularity, no necrosis, no mitoses
  • May show fibrosis and hyalinization
Microscopic (histologic) images

Images hosted on other servers:

Bronchial leiomyoma:
Bronchial leiomyoma: respiratory epithelium Respiratory epithelium

Respiratory epithelium

Actin

Actin

Desmin+, myogenin-

Desmin+, myogenin-


Vascular leiomyoma
Tumor (center)

Tumor (center)

Mature smooth muscle

Mature smooth muscle

Small pulmonary arteries

Small pulmonary arteries

SMA+

SMA+

Van Gieson elastin

Van Gieson elastin

Positive stains
Negative stains
Differential diagnosis
Additional references
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