Lung tumor
Adenocarcinoma
Micropapillary


Topic Completed: 1 October 2014

Minor changes: 4 July 2020

Revised: 31 January 2019, last major update October 2015

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: Micropapillary [title] lung


Negar Rassaei, M.D.
Page views in 2019: 2,135
Page views in 2020 to date: 1,365
Cite this page: Rassaei N. Micropapillary. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/lungtumormicropapillary.html. Accessed August 7th, 2020.
Definition / general
Prognostic factors
  • Often presents at late stage
  • Considered a poor prognostic variant due to more aggressive clinical course
  • Associated with higher rate of pleural invasion, nodal, intra- and extra-pulmonary metastasis
Case reports
Gross images
Missing Image

Gray white tumor

Microscopic (histologic) description
  • Either papillary tufts without fibrovascular core connected to alveolar walls or a detached shedding tumor within alveolar spaces
  • Also ring-like glandular structures within alveolar spaces and psammoma bodies
Microscopic (histologic) images
Missing Image

Micropapillary component

Missing Image

Stromal micropapillary pattern

Missing Image

Papillary and micropapillary structures

Missing Image

Resected lymph node

Missing Image

E cadherin, CD44

Missing Image

MUC1, D240, CD34

Positive stains
  • Has typical lung adenocarcinoma immunoprofile of CK7 (+), CK20 (-), TTF1 (+), and NapsinA (+)
Molecular / cytogenetics description
Additional references
Back to top