Mesenchymal tumors
Synovial sarcoma

Topic Completed: 1 September 2012

Minor changes: 16 September 2020

Copyright: 2003-2021,, Inc.

PubMed Search: pulmonary synovial sarcoma

Deepali Jain, M.D.
Page views in 2020: 2,497
Page views in 2021 to date: 465
Cite this page: Jain D. Synovial sarcoma. website. Accessed March 4th, 2021.
Definition / general
  • Rare tumor in lung
  • Associated with chest pain, hemoptysis, dyspnea, cough, fever
  • Rarely is cystic (Am J Surg Pathol 2010;34:1176)
  • 40 - 55% die of disease after 20 years followup, due to metastases to bone, CNS, liver, or invasion of adjacent organs
  • Tumors with SYT-SSX2 fusion proteins have 89% 5 year survival vs. 42% for tumors with SYT-SSX1 fusion protein
Case reports
Microscopic (histologic) description
  • Monophasic spindle cells or biphasic with epithelial and spindle cell component
  • Monophasic tumors have compact fascicles of hyperchromatic spindle cells with hemangiopericytoma-like areas, often punctuated by small arteries and capillaries in an irregular distribution
  • Poorly differentiated tumors have small, round blue cells resembling Ewing sarcoma / PNET
  • Rarely rhabdoid features
Positive stains
Negative stains
Molecular / cytogenetics description
  • t(X;18)(p11.2;icq11.2)
  • Produces either SYT-SSX1 or SYT-SSX2 fusion genes
Differential diagnosis
Back to top
Image 01 Image 02