Lymph nodes & spleen, nonlymphoid
Lymph nodes-inflammatory disorders
Progressive transformation of germinal centers

Topic Completed: 1 June 2006

Minor changes: 30 July 2020

Revised: 5 February 2019, last major update June 2006

Copyright: 2003-2020,, Inc.

PubMed Search: Progressive transformation of germinal centers

Page views in 2019: 6,116
Page views in 2020 to date: 4,041
Cite this page: DePond W. Progressive transformation of germinal centers. website. Accessed August 11th, 2020.
Definition / general
Microscopic (histologic) description
  • Germinal centers are markedly (3 - 5x) larger than normal, with indistinct margins; are composed of follicular mantle lymphocytes and extensive follicular dendritic cells
  • Tingible body macrophages are also present
  • Associated with more typical germinal centers
  • Large numbers of T cells are present
  • May have a few small hyaline vascular type germinal centers
  • Rarely have T cell rosettes
  • May have BCL2 expression in mantle B cells
Microscopic (histologic) images

AFIP images:
Positive stains
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