Lymph nodes & spleen, nonlymphoma

Lymph nodes-inflammatory / reactive disorders

Progressive transformation of germinal centers

Topic Completed: 1 June 2006

Minor changes: 12 May 2021

Copyright: 2003-2021,, Inc.

PubMed Search: Progressive transformation of germinal centers

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Cite this page: DePond W. Progressive transformation of germinal centers. website. Accessed October 25th, 2021.
Definition / general
Microscopic (histologic) description
  • Germinal centers are markedly (3 - 5x) larger than normal, with indistinct margins; are composed of follicular mantle lymphocytes and extensive follicular dendritic cells
  • Tingible body macrophages are also present
  • Associated with more typical germinal centers
  • Large numbers of T cells are present
  • May have a few small hyaline vascular type germinal centers
  • Rarely have T cell rosettes
  • May have BCL2 expression in mantle B cells
Microscopic (histologic) images

AFIP images
Positive stains
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