Lymph nodes & spleen, nonlymphoma

Lymph nodes-vascular lesions


Last author update: 1 December 2013
Last staff update: 18 July 2022

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PubMed Search: Angiomyolipoma[TI] lymph node

Patricia Tsang, M.D., M.B.A.
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Cite this page: Tsang P. Angiomyolipoma. website. Accessed September 30th, 2023.
Definition / general
  • Benign tumor associated with renal angiomyolipoma
  • Proliferation of adipose tissue, smooth muscle and thick walled vessels in variable proportions
  • Rare nodal involvement of renal angiomyolipoma likely due to multicentric tumor rather than metastasis (Int J Urol 2000;7:386, Arch Pathol Lab Med 1990;114:65)
  • Retroperitoneal and periaortic lymph nodes draining the involved kidney
  • Clonal process, consistent with neoplasm rather than hamartoma
  • Common progenitor cell differentiating into the 3 cell types (adipose tissue, smooth muscle and blood vessels) (Semin Diagn Pathol 1998;15:21)
Clinical features
  • Presents as renal mass with regional lymphadenopathy
  • May be associated with tuberous sclerosis
  • Fat poor angiomyolipoma can mimic renal cell carcinoma with nodal metastasis on radiograph
  • Indolent clinical course and slow growth
Case reports
  • Observation
  • Embolization of renal mass or renal conserving surgery
Microscopic (histologic) description
  • Haphazard adipose tissue and smooth muscle cells radiating from thick walled blood vessels
  • Ranges from sinusoidal involvement to massive replacement of nodal parenchyma
  • Smooth muscle may be epithelioid or pleomorphic
  • Infrequent mitoses
Microscopic (histologic) images

AFIP images

Lymph node

Positive stains
Molecular / cytogenetics description
  • Diploid DNA, consistent with benign behavior
Differential diagnosis
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