Lymph nodes & spleen, nonlymphoma
Lymph nodes-infectious / parasitic disorders

Topic Completed: 1 July 2013

Minor changes: 1 October 2020

Copyright: 2003-2021,, Inc.

PubMed Search: bCG [title] lymph nodes [title]

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Cite this page: DePond WD. bCG. website. Accessed January 23rd, 2021.
Definition / general
  • Post vaccination bacille Calmette-Guerin infection occurs in 1% of infants, although swelling usually subsides (Braz J Med Biol Res 2004;37:697)
  • Patients with normal immunity have complete recovery after postvaccination bCG infection after excision of infected lymph node; immunosuppressed patients may require antiTB therapy to avoid fatal disseminated infection (Am J Clin Pathol 2000;113:703)
Case reports
Microscopic (histologic) description
  • Patients with normal immunity: multiple epithelioid granulomas and Langhans giant cells; variable suppuration, minimal caseous necrosis, few acid fast bacteria identified with Ziehl-Neelsen stain
  • Immunosuppressed patients: histiocytes with abundant gray cytoplasm containing numerous acid fast bacilli, plump nuclei
Cytology description
  • Poorly to moderately cellular smears of epithelioid histiocytes in a granuloma pattern with occasional multinucleated Langerhans type giant cells, lymphocytes and neutrophils
  • Background is finely granular with necrotic debris
  • Isolated calcified spherules (Diagn Cytopathol 2001;25:134)
  • May be heavy involvement of acid fast bacilli (World J Surg Oncol 2003;1:25)
Additional references
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