Primary immunodeficiency disorders
Chronic granulomatous disease

Topic Completed: 1 July 2013

Minor changes: 17 February 2020

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PubMed Search: Chronic granulomatous disease [title] lymph nodes

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Cite this page: DePond W. Chronic granulomatous disease. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/lymphnodeschronicgranulomatousdisease.html. Accessed January 17th, 2021.
Definition / general
  • Due to congenital enzymatic defect of NADPH oxidase in granulocytes and monocytes
  • White blood cells cannot generate superoxide ion which kills microorganisms in lysosomes
  • Either Y linked or autosomal recessive
  • Diagnose with nitro blue tetrazolium test (almost always positive)
  • Clinically, patients have recurrent lymphadenitis, hepatosplenomegaly, skin rash, pulmonary edema
  • Anemia, leukocytosis, hypergammaglobulinemia
Case reports
Microscopic (histologic) description
  • Granulomas with central necrosis in lymph nodes and other organs
  • Pigment laden histiocytes
Microscopic (histologic) images

Images hosted on PathOut server:
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Childhood disease,
AFB stain -
contributed by
Dr. Mark R. Wick

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Childhood disease -
contributed by
Dr. Mark R. Wick

Missing Image

Childhood disease,
PAS stain -
contributed by
Dr. Mark R. Wick

Cytology description
Electron microscopy description
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