Lymph nodes & spleen, nonlymphoma
Lymph nodes-infectious / parasitic disorders

Topic Completed: 1 June 2013

Minor changes: 1 October 2020

Copyright: 2003-2021,, Inc.

PubMed Search: Coccidioides immitis [title] lymph nodes

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Cite this page: DePond WD. Coccidioides. website. Accessed January 24th, 2021.
Definition / general
  • Also called San Jaquin Valley Fever
  • Dimorphic fungus with distinct yeast and mold stages
  • Endemic to Lower Sonoran Desert (southwest US, Central and South America)
  • Usually self limiting, but more severe disease in immunocompromised hosts
Case reports
  • Culture (grows on all media)
  • Has enteroarthric conidia (alternating segments of hyphae undergo autolysis, while surviving segments form infective barrel shaped multinucleate arthroconidia)
Microscopic (histologic) description
  • Thick walled spherules 20 - 150 microns containing 3 - 5 micron endospores, surrounded by a giant cell granulomatous reaction
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