Lymph nodes & spleen, nonlymphoma

Lymph node & spleen-nonlymphoid neoplasms

Fibroblastic reticulum cell sarcoma

Last author update: 1 May 2014
Last staff update: 14 June 2021

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PubMed Search: Fibroblastic reticulum cell sarcoma

Patricia Tsang, M.D., M.B.A.
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Cite this page: Tsang P. Fibroblastic reticulum cell sarcoma. website. Accessed September 26th, 2023.
Definition / general
  • Rare malignant neoplasm of nodal stromal cells
  • Arises from fibroblastic reticular cells in the T cell zone of the nodal cortex
  • Fibroblastic reticular cells secrete chemokines (interleukin 7 and CCL19) responsible for naive T cell survival (Nat Immunol 2007;8:1255)
Case reports
  • 25 year old man with reticulum cell sarcoma of lymph node with mixed dendritic and fibroblastic features (Mod Pathol 2001;14:1059)
  • 71 year old woman with tumor of fibroblastic reticular cells of lymph node coincidental with an undifferentiated endometrial stromal sarcoma (APMIS 2011;119:216)
  • Surgery
Microscopic (histologic) description
  • Storiform or fascicular pattern of oval to spindle cells in a collagenized background
Cytology images

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Wright stain

Positive stains
Negative stains
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