Lymph nodes & spleen, nonlymphoma
Lymph node & spleen-nonlymphoid neoplasms
Fibroblastic reticulum cell sarcoma
Author: Patricia Tsang, M.D., M.B.A.
Last author update: 1 May 2014
Last staff update: 14 June 2021
Copyright: 2003-2024, PathologyOutlines.com, Inc.
PubMed Search: Fibroblastic reticulum cell sarcoma
Table of Contents
Definition / general | Pathophysiology | Case reports | Treatment | Microscopic (histologic) description | Cytology images | Positive stains | Negative stains | Differential diagnosis | Additional referencesCite this page: Tsang P. Fibroblastic reticulum cell sarcoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/lymphnodesfibroblasticreticulumcellsarcoma.html. Accessed April 18th, 2024.
Definition / general
- Rare malignant neoplasm of nodal stromal cells
Pathophysiology
- Arises from fibroblastic reticular cells in the T cell zone of the nodal cortex
- Fibroblastic reticular cells secrete chemokines (interleukin 7 and CCL19) responsible for naive T cell survival (Nat Immunol 2007;8:1255)
Case reports
- 25 year old man with reticulum cell sarcoma of lymph node with mixed dendritic and fibroblastic features (Mod Pathol 2001;14:1059)
- 71 year old woman with tumor of fibroblastic reticular cells of lymph node coincidental with an undifferentiated endometrial stromal sarcoma (APMIS 2011;119:216)
Treatment
- Surgery
Microscopic (histologic) description
- Storiform or fascicular pattern of oval to spindle cells in a collagenized background
Cytology images
Images hosted on other servers:
Wright stain
Positive stains
- CD31, vimentin, desmin, smooth muscle actin
- Cytokeratin variable
Differential diagnosis
Additional references
