Table of Contents
Definition / general | Pathophysiology | Case reports | Treatment | Microscopic (histologic) description | Cytology images | Positive stains | Negative stains | Differential diagnosis | Additional referencesCite this page: Tsang P. Fibroblastic reticulum cell sarcoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/lymphnodesfibroblasticreticulumcellsarcoma.html. Accessed September 26th, 2023.
Definition / general
- Rare malignant neoplasm of nodal stromal cells
Pathophysiology
- Arises from fibroblastic reticular cells in the T cell zone of the nodal cortex
- Fibroblastic reticular cells secrete chemokines (interleukin 7 and CCL19) responsible for naive T cell survival (Nat Immunol 2007;8:1255)
Case reports
- 25 year old man with reticulum cell sarcoma of lymph node with mixed dendritic and fibroblastic features (Mod Pathol 2001;14:1059)
- 71 year old woman with tumor of fibroblastic reticular cells of lymph node coincidental with an undifferentiated endometrial stromal sarcoma (APMIS 2011;119:216)
Treatment
- Surgery
Microscopic (histologic) description
- Storiform or fascicular pattern of oval to spindle cells in a collagenized background
Positive stains
- CD31, vimentin, desmin, smooth muscle actin
- Cytokeratin variable
Differential diagnosis
Additional references