Table of Contents
Definition / general | Case reports | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Electron microscopy descriptionCite this page: DePond W. Herpes simplex. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/lymphnodeshsv.html. Accessed May 27th, 2020.
Definition / general
- HSV lymphadenitis is very uncommon
- Usually inguinal nodes (Am J Clin Pathol 1991;95:709)
- Often associated with hematopoietic malignancies
Case reports
- 23 year old woman with lymphadenitis before appearance of cutaneous vulvar lesions (Arch Pathol Lab Med 1985;109:1043)
- 43 year old man with immunodeficiency (Clin Infect Dis 2002;34:1)
- 43 year old woman with mantle cell lymphoma (Arch Pathol Lab Med 2006;130:536)
- 59 year old man with HSV infection resembling Richter transformation (Am J Hematol 2001;68:287)
Microscopic (histologic) description
- Well circumscribed necrosis, follicular and paracortical hyperplasia (Histopathology 1991;19:355)
- Cells have intranuclear inclusions, particularly at edge of necrotic areas
- Also marked immunoblasts, T cell hyperplasia
Microscopic (histologic) images
Images hosted on PathOut server:
Herpes simplex lymphadenitis - contributed by Dr. Mark R. Wick
Images hosted on other servers:
Parafollicular expansion
Various images of tonsillar HSV infection
Figure 2: HSV inclusions
Figure 4: HSV1/2 immunostain
Interfollicular infiltrate of immunoblasts,
centroblasts, small lymphocytes
and occasional histiocytes and venule
with prominent endothelial cells
Positive stains
- HSV
Electron microscopy description
- Intranuclear and cytoplasmic virus particles (Am J Surg Pathol 1990;14:571)
