Table of Contents
Definition / general | Case reports | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Electron microscopy descriptionCite this page: DePond WD. Herpes simplex. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/lymphnodeshsv.html. Accessed January 16th, 2021.
Definition / general
- HSV lymphadenitis is very uncommon
- Usually inguinal nodes (Am J Clin Pathol 1991;95:709)
- Often associated with hematopoietic malignancies
Case reports
- 23 year old woman with lymphadenitis before appearance of cutaneous vulvar lesions (Arch Pathol Lab Med 1985;109:1043)
- 43 year old man with immunodeficiency (Clin Infect Dis 2002;34:1)
- 43 year old woman with mantle cell lymphoma (Arch Pathol Lab Med 2006;130:536)
- 59 year old man with HSV infection resembling Richter transformation (Am J Hematol 2001;68:287)
Microscopic (histologic) description
- Well circumscribed necrosis, follicular and paracortical hyperplasia (Histopathology 1991;19:355)
- Cells have intranuclear inclusions, particularly at edge of necrotic areas
- Also marked immunoblasts, T cell hyperplasia
Microscopic (histologic) images
Contributed by Mark R. Wick, M.D.
Herpes simplex lymphadenitis
Positive stains
- HSV
Electron microscopy description
- Intranuclear and cytoplasmic virus particles (Am J Surg Pathol 1990;14:571)
