Lymph nodes & spleen, nonlymphoid
Lymph nodes-inflammatory disorders
Hyaline deposits

Topic Completed: 1 June 2006

Minor changes: 30 July 2020

Revised: 5 February 2019, last major update June 2006

Copyright: 2003-2020,, Inc.

PubMed Search: Hyaline deposits lymph node

Page views in 2019: 2,232
Page views in 2020 to date: 1,545
Cite this page: DePond W. Hyaline deposits. website. Accessed August 3rd, 2020.
Definition / general
Microscopic (histologic) description
  • Extracellular eosinophilic material resembling amyloid but Congo Red negative
  • Hyaline sclerosis of small and midsized vessels of lymph nodes and organs (Blood 1995;86:1159)
Microscopic (histologic) images

Images hosted on other servers:

Rheumatoid arthritis and systemic sclerosis:

Hyaline deposits in interfollicular areas

Extensive replacement of node by eosinophilic material (also focal calcification)

Node replaced by
sarcoid-like granulomas
with prominent
hyaline material

Positive stains
  • Immunoglobulins
Negative stains
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