Lymph nodes & spleen, nonlymphoid
Lymph nodes-inflammatory disorders
Inflammatory pseudotumor

Topic Completed: 1 June 2006

Minor changes: 30 July 2020

Revised: 5 February 2019, last major update June 2006

Copyright: 2003-2020,, Inc.

PubMed Search: Inflammatory pseudotumor[TI] lymph node

Page views in 2019: 1,434
Page views in 2020 to date: 1,958
Cite this page: DePond W. Inflammatory pseudotumor. website. Accessed August 6th, 2020.
Definition / general
  • One or many lymph nodes are affected
  • Often fever, anemia, elevated erythrocyte sedimentation rate, hypergammaglobulinemia, prominent lymphadenopathy
  • Usually benign / reactive, not neoplastic and so distinct from inflammatory myofibroblastic tumor at this site (Hum Pathol 2001;32:1382)
Case reports
  • Steroids, NSAIDs
Microscopic (histologic) description
  • Varies from case to case
  • Storiform pattern of spindled fibroblasts or myofibroblasts in fibrous stroma of node with extension into lymphoid tissue and perinodal tissue
  • Vascular proliferation and mixed inflammatory infiltrate of plasma cells, immunoblasts, small lymphocytes, histiocytes, dendritic cells, neutrophils and fibroblasts
Microscopic (histologic) images

AFIP images:

Inflammatory pseudotumor of lymph node

Contributed by Dr. Mark R. Wick

Images hosted on other servers:

Tumor has hilar location in node

Spindle cells, plasma
cells, lymphocytes
and vascular

Interface between calcified tumor and lymph node

Hyalinized collagenous
tissue with psammoma
bodies and scattered
spindle cells

A: perivascular fibrosis
B: perivascular hyalinization of small vessels
C: intravascular fibrin thrombi
D: transmural lymphocytic infiltrate in pericapsular vessel

Cytology description
Negative stains
Molecular / cytogenetics description
  • No clonal T cell receptor gene rearrangements
Differential diagnosis
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