Lymph nodes & spleen, nonlymphoma

Lymph node-nonspecific findings

Inflammatory pseudotumor

Topic Completed: 1 June 2006

Minor changes: 13 October 2021

Copyright: 2003-2021,, Inc.

PubMed Search: Inflammatory pseudotumor[TI] lymph node

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Cite this page: DePond WD. Inflammatory pseudotumor. website. Accessed October 25th, 2021.
Definition / general
  • One or many lymph nodes are affected
  • Often fever, anemia, elevated erythrocyte sedimentation rate, hypergammaglobulinemia, prominent lymphadenopathy
  • Usually benign / reactive, not neoplastic and so distinct from inflammatory myofibroblastic tumor at this site (Hum Pathol 2001;32:1382)
Case reports
  • Steroids, NSAIDs
Microscopic (histologic) description
  • Varies from case to case
  • Storiform pattern of spindled fibroblasts or myofibroblasts in fibrous stroma of node with extension into lymphoid tissue and perinodal tissue
  • Vascular proliferation and mixed inflammatory infiltrate of plasma cells, immunoblasts, small lymphocytes, histiocytes, dendritic cells, neutrophils and fibroblasts
Microscopic (histologic) images

AFIP images

Inflammatory pseudotumor of lymph node

Contributed by Mark R. Wick, M.D.
Cytology description
Positive stains
Negative stains
Molecular / cytogenetics description
  • No clonal T cell receptor gene rearrangements
Differential diagnosis
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