Lymph nodes & spleen, nonlymphoma

Lymph node & spleen-nonlymphoid neoplasms

Interdigitating dendritic cell / reticulum cell sarcoma

Last author update: 1 June 2006
Last staff update: 7 March 2024 (update in progress)

Copyright: 2003-2024,, Inc.

PubMed Search: Interdigitating dendritic cell reticulum cell sarcoma lymph nodes

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Cite this page: DePond WD. Interdigitating dendritic cell / reticulum cell sarcoma. website. Accessed May 19th, 2024.
Definition / general
  • Also called interdigitating dendritic cell tumor
  • Very rare
  • Usually arises in lymph nodes with widespread lymphadenopathy but also in bladder, bowel, intestine, nasopharynx, salivary glands, skin, spleen, testis and tonsils
  • Aggressive behavior, with half dying of disease after an average of 7 months
  • Have same morphologic and immunohistochemical features as nonneoplastic interdigitating dendritic cells
  • Presence of another hematologic neoplasm is common
Case reports
Microscopic (histologic) description
  • Fascicles or whorls of paracortical tumor cells that spare the follicles and sinuses
  • Tumor cells are large and pleomorphic with abundant pale, eosinophilic cytoplasm and bizarre, grooved nuclei
  • May have tumor giant cells, mitotic activity, inflammatory infiltrate
Microscopic (histologic) images

AFIP images

Interdigitating dendritic cell sarcoma

Negative stains
Electron microscopy description
  • Interdigitating cytoplasmic processes but no desmosomes or other junctional complexes, no Birbeck granules
Additional references
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