Table of Contents
Definition / general | Case reports | Treatment | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Negative stains | Electron microscopy description | Differential diagnosis | Additional referencesCite this page: DePond WD. Interdigitating dendritic cell / reticulum cell sarcoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/lymphnodesinterdigitatingreticulum.html. Accessed June 2nd, 2023.
Definition / general
- Also called interdigitating dendritic cell tumor
- Very rare
- Usually arises in lymph nodes with widespread lymphadenopathy but also in bladder, bowel, intestine, nasopharynx, salivary glands, skin, spleen, testis and tonsils
- Aggressive behavior, with half dying of disease after an average of 7 months
- Have same morphologic and immunohistochemical features as nonneoplastic interdigitating dendritic cells
- Presence of another hematologic neoplasm is common
Case reports
- 20 year old woman with multifocal lymphadenopathy (Arch Pathol Lab Med 1994;118:183)
- 30 year old woman with cervical nodal involvement (Saudi Med J 2002;23:1281)
- 38 year old woman with cervical lymph node and breast involvement (Virchows Arch 2005;446:546)
- 41 year old man with cervical lymph node involvement (Zhonghua Xue Ye Xue Za Zhi 2005;26:232)
- 79 year old man with coexisting SLL in axillary node (Arch Pathol Lab Med 2006;130:544)
Treatment
- Chemotherapy (Leuk Lymphoma 2002;43:817)
Microscopic (histologic) description
- Fascicles or whorls of paracortical tumor cells that spare the follicles and sinuses
- Tumor cells are large and pleomorphic with abundant pale, eosinophilic cytoplasm and bizarre, grooved nuclei
- May have tumor giant cells, mitotic activity, inflammatory infiltrate
Microscopic (histologic) images
AFIP images
Interdigitating dendritic cell sarcoma
Positive stains
Electron microscopy description
- Interdigitating cytoplasmic processes but no desmosomes or other junctional complexes, no Birbeck granules
Differential diagnosis
Additional references
