Lymph nodes & spleen, nonlymphoma

Lymph node & spleen-nonlymphoid neoplasms

Interdigitating dendritic cell / reticulum cell sarcoma

Topic Completed: 1 June 2006

Minor changes: 11 May 2021

Copyright: 2003-2022,, Inc.

PubMed Search: Interdigitating dendritic cell reticulum cell sarcoma lymph nodes

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Cite this page: DePond WD. Interdigitating dendritic cell / reticulum cell sarcoma. website. Accessed January 18th, 2022.
Definition / general
  • Also called interdigitating dendritic cell tumor
  • Very rare
  • Usually arises in lymph nodes with widespread lymphadenopathy but also in bladder, bowel, intestine, nasopharynx, salivary glands, skin, spleen, testis and tonsils
  • Aggressive behavior, with half dying of disease after an average of 7 months
  • Have same morphologic and immunohistochemical features as nonneoplastic interdigitating dendritic cells
  • Presence of another hematologic neoplasm is common
Case reports
Microscopic (histologic) description
  • Fascicles or whorls of paracortical tumor cells that spare the follicles and sinuses
  • Tumor cells are large and pleomorphic with abundant pale, eosinophilic cytoplasm and bizarre, grooved nuclei
  • May have tumor giant cells, mitotic activity, inflammatory infiltrate
Microscopic (histologic) images

AFIP images

Various images

Negative stains
Electron microscopy description
  • Interdigitating cytoplasmic processes but no desmosomes or other junctional complexes, no Birbeck granules
Additional references
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