Lymph nodes & spleen, nonlymphoma
Lymph nodes-inflammatory / reactive disorders
Kimura disease

Topic Completed: 1 June 2006

Minor changes: 10 August 2020

Copyright: 2003-2021,, Inc.

PubMed Search: Kimura disease[TI]

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Cite this page: DePond W. Kimura disease. website. Accessed January 16th, 2021.
Definition / general
  • Chronic inflammatory disorder of unknown etiology
  • Endemic in Asia, affects young men
  • Often subcutaneous mass of head and neck (including salivary glands), associated with regional lymphadenopathy but normal overlying skin
  • Lesions persist and may recur after excision
Case reports
  • Excision, radiation therapy, cyclosporine
Microscopic (histologic) description
  • Germinal center hyperplasia with polykaryocytes, fibrosis and proteinaceous material in germinal centers
  • Folliculolysis, interfollicular eosinophils and eosinophilic abscesses
  • Increased paracortical plasma cells
  • Variable hyalinized vessels
  • Soft tissue lesions show proliferation of thin walled vessels with eosinophilia
Microscopic (histologic) images

Images hosted on other servers:

Skin: various images

Cytology description
  • Polymorphous lymphoid population with significant eosinophils, fragments of collagenous tissue, endothelial cells and occasional polykaryocytes (Acta Cytol 2002;46:357)
Positive stains
Molecular / cytogenetics description
  • May be clonal rearrangement of T cell receptor delta gene
Differential diagnosis
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