Table of Contents
Definition / general | Laboratory | Case reports | Treatment | Microscopic (histologic) description | Microscopic (histologic) images | Cytology description | Positive stains | Molecular / cytogenetics description | Differential diagnosis | Additional referencesCite this page: DePond W. Kimura disease. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/lymphnodeskimurasdisease.html. Accessed May 24th, 2020.
Definition / general
- Chronic inflammatory disorder of unknown etiology
- Endemic in Asia, affects young men
- Often subcutaneous mass of head and neck (including salivary glands), associated with regional lymphadenopathy but normal overlying skin
- Lesions persist and may recur after excision
Laboratory
- Increased serum IgE, peripheral eosinophilia (Am J Surg Pathol 1988;12:843)
Case reports
- 3 year old Japanese boy with with epithelioid eosinophilic granulomatous reaction and apoptotic eosinophils (Hum Pathol 2002;33:561)
- 62 year old man with clonal T cell receptor delta rearrangement (Am J Surg Pathol 2002;26:1083)
- Patient with coexisting angiolymphoid hyperplasia with eosinophilia (Int J Dermatol 2006;45:139)
Treatment
- Excision, radiation therapy, cyclosporine
Microscopic (histologic) description
- Germinal center hyperplasia with polykaryocytes, fibrosis and proteinaceous material in germinal centers
- Folliculolysis, interfollicular eosinophils and eosinophilic abscesses
- Increased paracortical plasma cells
- Variable hyalinized vessels
- Soft tissue lesions show proliferation of thin walled vessels with eosinophilia
Microscopic (histologic) images
Images hosted on other servers:
Skin: various images
Cytology description
- Polymorphous lymphoid population with significant eosinophils, fragments of collagenous tissue, endothelial cells and occasional polykaryocytes (Acta Cytol 2002;46:357)
Positive stains
- IgE reticular networks in germinal centers (Am J Surg Pathol 1989;13:177)
Molecular / cytogenetics description
- May be clonal rearrangement of T cell receptor delta gene
Differential diagnosis
- Angiolymphoid hyperplasia with eosinophilia: also called epithelioid hemangioma; affects skin of older Caucasian men with multiple small papules, blood vessels are thick walled with prominent epithelioid endothelial cells
- Progressive transformation of lymph nodes
Additional references
