Lymph nodes & spleen, nonlymphoma
Lymph nodes-inflammatory / reactive disorders
Kimura disease

Topic Completed: 1 June 2006

Minor changes: 12 April 2021

Copyright: 2003-2021,, Inc.

PubMed Search: Kimura disease[TI]

Christopher S. Hale, M.D.
F. Zahra Aly, M.D., Ph.D.
Page views in 2020: 10,125
Page views in 2021 to date: 3,791
Cite this page: Hale C, DePond W, Tankchi S, Aly FZ. Kimura disease. website. Accessed April 15th, 2021.
Definition / general
  • Rare chronic inflammatory disorder of deep subcutaneous tissue, etiology unknown (Arch Pathol Lab Med 2007;131:650)
  • Usually head and neck, often associated with regional lymphadenopathy or salivary gland involvement
  • Usually affects Asian males but similar presentation in US (Am J Surg Pathol 2004;28:505)
  • Almost always affects nodal sites; often associated dermal involvement
  • Usually peripheral blood eosinophilia and elevated serum IgE
  • Benign, reactive, chronic and indolent but may clinically simulate a neoplasm
  • May recur, no / rare death from disease
  • Unknown infectious agent is presumed to cause an immunologic response
Case reports
  • Excision, radiation therapy, cyclosporine
  • May recur
Clinical images

Images hosted on other servers:

Lesion on buttock

Gross description
  • Large tumor-like lesions
Microscopic (histologic) description
  • Germinal center hyperplasia with polykaryocytes, fibrosis and proteinaceous material in germinal centers
  • Folliculolysis, interfollicular eosinophils and eosinophilic abscesses
  • Postcapillary venule proliferation with variable fibrosis
  • Increased paracortical plasma cells
  • Variable hyalinized vessels
  • Soft tissue lesions show proliferation of thin walled vessels with eosinophilia
Microscopic (histologic) images

Images hosted on other servers:
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Parotid gland

Bottom heavy inflammation

Follicle and numerous eosinophils

Cytology description
  • Polymorphous lymphoid population with significant eosinophils, fragments of collagenous tissue, endothelial cells and occasional polykaryocytes (Acta Cytol 2002;46:357)
Positive stains
Molecular / cytogenetics description
  • May be clonal rearrangement of T cell receptor delta gene
Differential diagnosis
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