Lymph nodes & spleen, nonlymphoma
Lymph nodes-vascular lesions
Kaposi sarcoma

Topic Completed: 1 June 2006

Minor changes: 16 October 2020

Copyright: 2003-2021,, Inc.

PubMed Search: Kaposi sarcoma[TI] lymph node

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Cite this page: DePond WD. Kaposi sarcoma. website. Accessed April 13th, 2021.
Definition / general
  • Difficult to detect early involvement; often best diagnosis is atypical vascular proliferation suggestive of early Kaposi sarcoma
  • May coexist with leukemia, lymphoma, Castleman disease or mycobacterial spindle cell tumor (Am J Surg Pathol 1999;23:656)
  • Classic form: elderly men of Jewish or Mediterranean descent; skin lesions of lower extremities with only rare nodal involvement; indolent for 10 - 15 years, then systemic lesions or lymphoreticular malignancies
  • African (endemic) form: young adults, usually men with indolent skin involvement, progressive large exophytic or deeply invasive tumors or occasional regional nodal involvement
  • Childhood form: children 2 - 13 years, usually boys, HIV negative with lymphadenopathy but usually no skin lesions; death within 1 - 3 years
  • HIV associated: usually homosexual men, often disseminated involving mucocutaneous sites, lymph nodes, GI tract and lungs
  • Transplant associated: local or systemic (Transplant Proc 2004;36:2145, Transplant Proc 2005;37:967)
Case reports
Gross description
  • Often multifocal
Microscopic (histologic) description
  • Resembles skin tumors
  • Curved fascicles of spindle cells separated by slit-like vascular spaces with extravasated red blood cells and frequent mitotic figures
  • Spindle cells have pale cytoplasm, elongated nuclei, indistinct nucleoli; often individual cell necrosis
  • Initially subcapsular but extends throughout node and into perinodal tissue
  • Almost always has PAS+ diastase resistant, PTAH+ hyaline globules
  • May have accompanying lymphocytes, plasma cells, histiocytes and immunoblasts, hemosiderin deposits
  • May resemble Castleman disease
Microscopic (histologic) images

Case #307



Cytology images

Case #307

Various images

Positive stains
Negative stains
Molecular / cytogenetics description
Additional references
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