Lymph nodes & spleen, nonlymphoma
Lymph nodes-inflammatory / reactive disorders
Mantle cell / marginal zone hyperplasia

Topic Completed: 1 June 2006

Minor changes: 12 August 2020

Copyright: 2003-2021,, Inc.

PubMed Search: Mantle cell marginal zone hyperplasia

Page views in 2020: 1,012
Page views in 2021 to date: 30
Cite this page: DePond W. Mantle cell / marginal zone hyperplasia. website. Accessed January 16th, 2021.
Definition / general
  • Gene rearrangement studies and followup recommended to rule out occult lymphoma in cases with clear cells (Am J Clin Pathol 2001;116:550)
  • Marginal zone hyperplasia is rare (except in mesenteric nodes) but does occur in reactive nodes (APMIS 2002;110:325)
Microscopic (histologic) description
  • Monomorphic proliferation of small lymphocytes with clear cytoplasm and round nuclei
  • No pericapsular infiltration, sinuses are identifiable, scattered reactive follicles
Microscopic (histologic) images

Contributed by Dr. Mark R. Wick

Cortical hyperplasia

Positive stains
Negative stains
  • No light chain restriction
Molecular / cytogenetics description
  • Usually negative
Back to top
Image 01 Image 02