Lymph nodes & spleen, nonlymphoma

Pigment / foreign material


Topic Completed: 1 June 2014

Minor changes: 12 August 2020

Copyright: 2003-2021,, Inc.

PubMed Search: Melanosis [title] lymph node

Jayalakshmi Balakrishna, M.D.
Page views in 2020: 1,024
Page views in 2021 to date: 722
Cite this page: Balakrishna J. Melanosis. website. Accessed October 28th, 2021.
Definition / general
  • A rare manifestation of a completely regressed melanoma
  • Tumoral melanosis
  • Nodular melanosis
  • Nodal melanosis
  • Very rare in lymph nodes
  • Sentinel lymph nodes of regressed melanoma
  • Mesenteric lymph nodes
  • Possibilities include:
    • A regressed focus of metastatic melanoma
    • Melanophages migrating to the lymph node from the primary lesion
Clinical features
  • Enlarged lymph nodes
  • Yellow brown spindle bodies in mesenteric nodes may be due to melanosis coli (Histopathology 1978;2:47)
  • The paucity of cases precludes adequate evaluation of long term implications and treatment outcomes
Case reports
Gross description
  • Enlarged lymph nodes with or without brown pigment deposition
Microscopic (histologic) description
  • Subcapsular and sinusoidal accumulation of pigmented cells with vesicular chromatin and inconspicuous nucleoli
  • The cells may be spindle shaped or epithelioid
Microscopic (histologic) images

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Melanosis Coli in a pericolonic lymph node

Positive stains
Negative stains
Differential diagnosis
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