Lymph nodes & spleen, nonlymphoid
Lymph nodes-inclusions, pigment, ectopic cells or tissue
Müllerian


Topic Completed: 1 July 2014

Minor changes: 29 July 2020

Revised: 1 February 2019, last major update July 2014

Copyright: 2003-2020, PathologyOutlines.com, Inc.

PubMed Search: Müllerian inclusions and cysts


Jayalakshmi Balakrishna, M.D.
Page views in 2019: 1,206
Page views in 2020 to date: 807
Cite this page: Balakrishna J. Müllerian. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/lymphnodesmullerianinclusioncysts.html. Accessed August 6th, 2020.
Definition / general
  • Benign glandular inclusions lined by salpingeal or ovarian epithelium with no endometrial stroma or hemosiderophages
Terminology
  • Also called endosalpingiosis
Sites
Pathophysiology
  • Theories include:
    • Passage of epithelial cells through the tubal ostium for implantation in the peritoneum following peeling, followed by transportation by the lymphatic route to reach the pelvic lymph node
    • Metaplastic origin from the peritoneum
    • Foci of endometriosis
    • Vestiges of paramesonephricus ducts
    • Metastases from ovarian serous borderline tumors (Am J Surg Pathol 2000;24:710)
Clinical features
  • Incidental finding / enlarged lymph nodes
Case reports
Treatment
  • Benign process, with no clinical significance
Gross description
  • Enlarged lymph nodes
Microscopic (histologic) description
  • Glandular / cystic inclusions lined by cuboidal / columnar cells with a Müllerian or coelomic appearance commonly found in the capsule
  • Psammoma bodies are common
  • May undergo squamous metaplasia
  • No / rare mitotic figures, no / mild atypia, no desmoplastic stroma, no endometrial stroma
Microscopic (histologic) images

AFIP images
Missing Image

In pelvic lymph node

Positive stains
Differential diagnosis
  • Metastasis from borderline / malignant ovarian tumors or uterine carcinomas
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