Lymph nodes & spleen, nonlymphoma
Lymph nodes-inclusions, pigment, ectopic cells or tissue
Nevus cells

Topic Completed: 1 July 2013

Minor changes: 28 October 2020

Copyright: 2003-2021,, Inc.

PubMed Search: Nevus cells [title]

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Cite this page: DePond WD. Nevus cells. website. Accessed January 18th, 2021.
Definition / general
Microscopic (histologic) description
  • Single cells, linear arrangements or aggregates of small, round / oval nevus cells with moderate pale / clear cytoplasm, round nuclei with fine chromatin, no prominent nucleoli or pleomorphism, usually within fibrous capsule and trabeculae, but also within nodal parenchyma (Am J Surg Pathol 2003;27:673) or surrounding a small vessel (Am J Surg Pathol 1996;20:834)
Microscopic (histologic) images

AFIP images
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Nevus cells in lymph node

Contributed by Dr. Mark R. Wick
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Nevocytic rest

Images hosted on other servers:

Left-benign nevus
cells, right-infiltrating
lobular carcinoma

Benign nevus cells within
capsule and vessel of
perinodal adipose tissue

Negative stains
Differential diagnosis
  • Blue nevus: also spindled / dendritic cells with heavy pigmentation
  • Metastatic carcinoma or melanoma: usually not confined to capsule, atypia, mitotic figures, different immunostaining
  • Spitz nevus: larger cells with abundant eosinophilic cytoplasm, vesicular nuclei with prominent nucleoli
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