Lymph nodes & spleen, nonlymphoma
Lymph nodes-infectious / parasitic disorders
Parvovirus B19

Topic Completed: 1 June 2006

Minor changes: 29 October 2020

Copyright: 2003-2021,, Inc.

PubMed Search: Parvovirus B19 lymph node

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Cite this page: DePond WD. Parvovirus B19. website. Accessed January 16th, 2021.
Definition / general
  • In adults, parvovirus B19 infection is associated with fever (81%), arthralgia / myalgia (62%), skin rash (48%), general fatigue (43%), lymphadenopathy (38%) and edema (38%) (Intern Med 2002;41:295)
  • May be associated with hemophagocytic syndrome (Br J Haematol 1997;96:868)
  • PCR
  • Immunohistochemistry
Case reports
Microscopic (histologic) description
  • Massive nodular histiocytic proliferation resembling Kikuchi disease with prominent apoptosis but no necrosis
  • One case showed florid reactive hyperplasia with paracortical expansion, neutrophils and hemophagocytosis (Pathol Int 1998;48:829)
Microscopic (histologic) images

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Prominent nodules of histiocytes

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