Lymph nodes & spleen, nonlymphoma

Lymph node & spleen-nonlymphoid neoplasms

Plasmacytoma



Last author update: 1 June 2006
Last staff update: 1 August 2022

Copyright: 2003-2023, PathologyOutlines.com, Inc.

PubMed Search: Plasmacytoma[TI] lymph nodes

Page views in 2022: 2,609
Page views in 2023 to date: 237
Cite this page: DePond W. Plasmacytoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/lymphnodesplasmacytoma.html. Accessed February 7th, 2023.
Definition / general
  • Very rare (< 50 reported cases)
  • Diagnosis of primary plasmacytoma of lymph node requires exclusion of extramedullary plasmacytoma (15% of upper respiratory tract plasmacytomas metastasize to cervical nodes) and myeloma (40% of high stage myelomas metastasize to nodes)
  • 2/3 male; median age 59 years (range 39 - 76 years)
  • Often involves cervical nodes
  • Similar survival to other extramedullary plasmacytomas, although does not progress to myeloma (Am J Clin Pathol 2001;115:119, Hum Pathol 1997;28:1083)
Case reports
Treatment
  • Surgery and radiotherapy
Microscopic (histologic) description
  • Similar to plasmacytomas outside lymph node
  • Dense, monotonous infiltrate of plasma cells that effaces nodal architecture
  • Cells vary from mature to binucleated to anaplastic
  • Plasmablastic if amphophilic to basophilic cytoplasm with small Golgi zone and large vesicular nuclei with prominent central nucleoli
  • Anaplastic if marked pleomorphism and irregular foldings in nuclear membranes
  • May have amyloid deposits
Microscopic (histologic) images

AFIP images

Plasmacytoma

Plasmacytoma

With crystalloids

With amyloid deposition


With blood lakes

With myxoid stroma

Plasmablastic plasmacytoma of nasopharynx

Anaplastic plasmacytoma

Immunohistochemistry

Positive stains
  • Immunoglobulin light chain restriction
  • Usually positive for CD79a, EMA
  • Variable CD43 and CD45RO
Negative stains
Molecular / cytogenetics description
  • Negative for KSHV / HHV8
Differential diagnosis
Back to top
Image 01 Image 02