Lymph nodes & spleen, nonlymphoma

Lymph node & spleen-nonlymphoid neoplasms


Last author update: 1 June 2006
Last staff update: 1 August 2022

Copyright: 2003-2023,, Inc.

PubMed Search: Plasmacytoma[TI] lymph nodes

Page views in 2022: 2,609
Page views in 2023 to date: 237
Cite this page: DePond W. Plasmacytoma. website. Accessed February 7th, 2023.
Definition / general
  • Very rare (< 50 reported cases)
  • Diagnosis of primary plasmacytoma of lymph node requires exclusion of extramedullary plasmacytoma (15% of upper respiratory tract plasmacytomas metastasize to cervical nodes) and myeloma (40% of high stage myelomas metastasize to nodes)
  • 2/3 male; median age 59 years (range 39 - 76 years)
  • Often involves cervical nodes
  • Similar survival to other extramedullary plasmacytomas, although does not progress to myeloma (Am J Clin Pathol 2001;115:119, Hum Pathol 1997;28:1083)
Case reports
  • Surgery and radiotherapy
Microscopic (histologic) description
  • Similar to plasmacytomas outside lymph node
  • Dense, monotonous infiltrate of plasma cells that effaces nodal architecture
  • Cells vary from mature to binucleated to anaplastic
  • Plasmablastic if amphophilic to basophilic cytoplasm with small Golgi zone and large vesicular nuclei with prominent central nucleoli
  • Anaplastic if marked pleomorphism and irregular foldings in nuclear membranes
  • May have amyloid deposits
Microscopic (histologic) images

AFIP images



With crystalloids

With amyloid deposition

With blood lakes

With myxoid stroma

Plasmablastic plasmacytoma of nasopharynx

Anaplastic plasmacytoma


Positive stains
  • Immunoglobulin light chain restriction
  • Usually positive for CD79a, EMA
  • Variable CD43 and CD45RO
Negative stains
Molecular / cytogenetics description
  • Negative for KSHV / HHV8
Differential diagnosis
Back to top
Image 01 Image 02