Table of Contents
Definition / general | Case reports | Microscopic (histologic) description | Microscopic (histologic) images | Cytology descriptionCite this page: DePond WD. Sinus histiocytosis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/lymphnodessinushistiocytosis.html. Accessed January 24th, 2021.
Definition / general
- Also called sinus hyperplasia
- Nonspecific finding associated with various etiologies (benign or malignant), including postprosthesis
- May represent pregranulomatous phase of sarcoidosis (Am J Surg Pathol Acta Histochem 2006;107:473)
- Rarely occurs in pelvic nodes of prostate cancer and axillary nodes of breast cancer patients (Cancer 1997;80:277)
Case reports
- 16 year old girl with parvovirus (J Clin Pathol 2005;58:872)
- 68 year old woman with postarthroplasty histiocytic lymphadenopathy (Arch Gynecol Obstet 2004;269:217, J Urol 1997;158:128)
- 70 year old diabetic patient with signet ring cell sinus histiocytosis resembling carcinoma (Am J Clin Pathol 1989;92:509, Int J Clin Oncol 2003;8:184)
Microscopic (histologic) description
- Dilated and prominent sinuses, often containing increased macrophages or sinus lining cells
- May resemble signet ring cell carcinoma cells but lack atypia and are mucin negative
Microscopic (histologic) images
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Sinus histiocytosis
Cytology description
- Polygonal histiocytes with rounded nuclei (Acta Cytol 1998;42:1347)
