Lymph nodes & spleen, nonlymphoma

Lymph nodes-inflammatory / reactive disorders

Systemic lupus erythematosus



Last author update: 1 June 2006
Last staff update: 6 December 2021

Copyright: 2003-2023, PathologyOutlines.com, Inc.

PubMed Search: Systemic lupus erythematosus[TI] lymph nodes

Page views in 2022: 3,889
Page views in 2023 to date: 405
Cite this page: DePond WD. Systemic lupus erythematosus. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/lymphnodessle.html. Accessed February 6th, 2023.
Definition / general
  • Most SLE patients have cervical lymphadenopathy
Case reports
Microscopic (histologic) description
  • Architectural preservation but follicular hyperplasia with variable sized follicles, increased vascularity, interfollicular immunoblasts and plasma cells
  • Often well circumscribed areas of paracortical necrosis with necrosis of small vessels (APMIS 2001;109:141)
  • Occasionally DNA deposition / hematoxylin bodies (hematoxyphilic material) in stroma, sinuses and blood vessel walls
  • May have giant follicles (APMIS 2005;113:558), often disarray of follicular dendritic cell network (Pathol Int 2000;50:304), no / rare granulomas, no / rare neutrophils
Microscopic (histologic) images

Images hosted on other servers:

Necrotizing lymphadenopathy

Cytology description
  • Typical and atypical immunoblasts, plasma cells, occasional Reed-Sternberg-like cells and dispersed hematoxylin bodies (Acta Cytol 2000;44:67)
Positive stains
Differential diagnosis
Back to top
Image 01 Image 02