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Lymph nodes & spleen, nonlymphoid
Lymph nodes-infectious / parasitic disorders
Syphilis


Topic Completed: 1 June 2006

Revised: 3 February 2019, last major update June 2006

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PubMed Search: Syphilis lymph nodes


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Table of Contents
Definition / general | Primary syphilis | Secondary syphilis | Tertiary syphilis
Cite this page: DePond W. Syphilis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/lymphnodessyphilis.html. Accessed August 13th, 2020.
Definition / general
  • Due to Treponema pallidum
Primary syphilis
Definition / general
  • Solitary inguinal lymphadenopathy associated with syphilitic chancre

Diagnosis

Microscopic (histologic) description
  • Capsular and pericapsular fibrosis, follicular hyperplasia, diffuse interfollicular plasma cells, prominent endarteritis outside the capsule
  • Noncaseating granulomas and abscesses are rare
  • Spirochetes easiest to identify within blood vessel walls

Microscopic (histologic) images

Images hosted on PathOut server:

AFIP images:

Luetic (syphilitic) lymphadenopathy


Contributed by Dr. Mark R. Wick:

Syphilis lymphadenitis



Positive stains
Secondary syphilis
Microscopic (histologic) description
  • Follicular hyperplasia
Tertiary syphilis
Definition / general
  • Localized lymph node enlargement
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