Primary syphilis
Definition / general
Diagnosis
Microscopic (histologic) description
Microscopic (histologic) images
AFIP images
Contributed by Mark R. Wick, M.D.
Positive stains
- Solitary inguinal lymphadenopathy associated with syphilitic chancre
Diagnosis
- PCR (including FNA of inguinal nodes, Lancet 2002;360:388)
- Southern blotting
- Immunostains
Microscopic (histologic) description
- Capsular and pericapsular fibrosis, follicular hyperplasia, diffuse interfollicular plasma cells, prominent endarteritis outside the capsule
- Noncaseating granulomas and abscesses are rare
- Spirochetes easiest to identify within blood vessel walls
Microscopic (histologic) images
AFIP images
Luetic (syphilitic) lymphadenopathy
Contributed by Mark R. Wick, M.D.
Syphilis lymphadenitis
Positive stains
- Warthin-Starry
- Immunostains
