Lymph nodes & spleen, nonlymphoma

Lymph nodes-infectious / parasitic disorders

Syphilis



Topic Completed: 1 June 2006

Minor changes: 4 November 2020

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PubMed Search: Syphilis lymph nodes

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Cite this page: DePond WD. Syphilis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/lymphnodessyphilis.html. Accessed October 23rd, 2021.
Definition / general
  • Due to Treponema pallidum
Primary syphilis
Definition / general
  • Solitary inguinal lymphadenopathy associated with syphilitic chancre

Diagnosis

Microscopic (histologic) description
  • Capsular and pericapsular fibrosis, follicular hyperplasia, diffuse interfollicular plasma cells, prominent endarteritis outside the capsule
  • Noncaseating granulomas and abscesses are rare
  • Spirochetes easiest to identify within blood vessel walls

Microscopic (histologic) images

AFIP images

Luetic (syphilitic) lymphadenopathy


Contributed by Mark R. Wick, M.D.

Syphilis lymphadenitis



Positive stains
Secondary syphilis
Microscopic (histologic) description
  • Follicular hyperplasia
Tertiary syphilis
Definition / general
  • Localized lymph node enlargement
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