Lymph nodes & spleen, nonlymphoid
Lymph nodes-infectious / parasitic disorders

Topic Completed: 1 June 2006

Revised: 3 February 2019, last major update June 2006

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Syphilis lymph nodes

Page views in 2019: 1,327
Page views in 2020 to date: 880
Cite this page: DePond W. Syphilis. website. Accessed August 13th, 2020.
Definition / general
  • Due to Treponema pallidum
Primary syphilis
Definition / general
  • Solitary inguinal lymphadenopathy associated with syphilitic chancre


Microscopic (histologic) description
  • Capsular and pericapsular fibrosis, follicular hyperplasia, diffuse interfollicular plasma cells, prominent endarteritis outside the capsule
  • Noncaseating granulomas and abscesses are rare
  • Spirochetes easiest to identify within blood vessel walls

Microscopic (histologic) images

Images hosted on PathOut server:

AFIP images:

Luetic (syphilitic) lymphadenopathy

Contributed by Dr. Mark R. Wick:

Syphilis lymphadenitis

Positive stains
Secondary syphilis
Microscopic (histologic) description
  • Follicular hyperplasia
Tertiary syphilis
Definition / general
  • Localized lymph node enlargement
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