Lymph nodes & spleen, nonlymphoma

Lymph nodes-infectious / parasitic disorders


Topic Completed: 1 June 2006

Minor changes: 4 November 2020

Copyright: 2003-2021,, Inc.

PubMed Search: Syphilis lymph nodes

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Page views in 2021 to date: 1,354
Cite this page: DePond WD. Syphilis. website. Accessed October 23rd, 2021.
Definition / general
  • Due to Treponema pallidum
Primary syphilis
Definition / general
  • Solitary inguinal lymphadenopathy associated with syphilitic chancre


Microscopic (histologic) description
  • Capsular and pericapsular fibrosis, follicular hyperplasia, diffuse interfollicular plasma cells, prominent endarteritis outside the capsule
  • Noncaseating granulomas and abscesses are rare
  • Spirochetes easiest to identify within blood vessel walls

Microscopic (histologic) images

AFIP images

Luetic (syphilitic) lymphadenopathy

Contributed by Mark R. Wick, M.D.

Syphilis lymphadenitis

Positive stains
Secondary syphilis
Microscopic (histologic) description
  • Follicular hyperplasia
Tertiary syphilis
Definition / general
  • Localized lymph node enlargement
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