Lymphoma & related disorders

Hodgkin lymphoma

CHL lymphocyte depleted

Last author update: 1 August 2011
Last staff update: 2 June 2022

Copyright: 2002-2022,, Inc.

PubMed Search: "Lymphocyte depleted" classic Hodgkin lymphoma

Dragos C. Luca, M.D.
Lauren Smith, M.D.
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Cite this page: Luca DC, Smith L. CHL lymphocyte depleted. website. Accessed July 6th, 2022.
Definition / general
  • Most historic cases are actually anaplastic non-Hodgkin lymphoma, diffuse large B cell lymphoma or syncytial variant of nodular sclerosing Hodgkin lymphoma (Leuk Lymphoma 2009;50:937)
  • < 1% of all classic Hodgkin lymphoma in Western countries (rarest subtype); more common in developing countries
  • Often HIV associated
  • Median age 30 - 37 years
  • Male predominance (60 - 75%)
  • 90% have subdiaphragmatic disease or organomegaly
  • Predilection for retroperitoneal lymph nodes, abdominal organs and bone marrow
  • Marrow involvement is common (54%); 50% have peripheral adenopathy
Clinical features
  • Aggressive course prior to modern therapy, still seen in parts of Europe and developing countries
  • Comparable with other classic Hodgkin lymphoma in Western countries
  • Poor prognosis in HIV cases
  • All Classic Hodgkin lymphoma subtypes are treated similarly with either chemotherapy alone or chemotherapy plus external beam radiation
Microscopic (histologic) description
  • Either diffuse fibrosis or reticular forms

Diffuse fibrosis form
  • Complete effacement of nodal architecture by abundant disorderly connective tissue with PAS+ fibrinoid material and hypocellular background
  • Rare Reed-Sternberg cells
  • Classify as nodular sclerosis classic Hodgkin lymphoma if nodular and sclerotic

Reticular form
  • No disorderly connective tissue, numerous bizarre Reed-Sternberg cells, often in sheets, with few lymphocytes

Bone marrow
  • Rare Reed-Sternberg cells in amorphous, nonbirefringent eosinophilic background material and inflammatory infiltrate
  • Multiple sections / levels often required for diagnosis
  • Uninvolved marrow is normocellular with increased eosinophils (Am J Surg Pathol 1986;10:219)

  • May resemble mixed cellularity classic Hodgkin lymphoma
  • Sarcomatous pattern with pleomorphic HRS cells difficult to differentiate from anaplastic large cell lymphoma
  • May have coagulative necrosis or sinusoidal invasion
Microscopic (histologic) images

AFIP images

Diffuse fibrosis and a Reed-Sternberg cell

Numerous Hodgkin cells in a background of fibrosis

Images hosted on other servers:

Various images

Reticular form (also called sarcomatous)

Diffuse fibrosis form

Reed-Sternberg cell staining

Other images

Positive stains
Negative stains
Differential diagnosis
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