Mandible & maxilla

Benign bone and cartilage tumors

Desmoplastic fibroma

Topic Completed: 1 October 2013

Minor changes: 29 December 2020

Copyright: 2004-2021,, Inc.

PubMed Search: Desmoplastic fibroma [title]

Nat Pernick, M.D.
Page views in 2020: 1,313
Page views in 2021 to date: 1,693
Cite this page: Pernick N. Desmoplastic fibroma. website. Accessed October 25th, 2021.
Definition / general
  • Rare, mean 23 years, range 1 - 75 years
  • Intraosseous component of soft tissue fibromatosis
  • May be due to local trauma; may be part of Gardner syndrome
  • Benign, but up to 35% recur, does not metastasize
Case reports
  • Wide local excision
Gross description
  • Firm, rubbery, white, nonencapsulated, fibrous appearing lesion
Microscopic (histologic) description
  • Poorly demarcated lesion with interlacing or fascicular pattern of mature fibrous tissue composed of small fibroblasts with no / minimal mitotic activity and abundant collagenous stroma
  • No osteoid, no epithelial rests, rare multinucleated giant cells
Microscopic (histologic) images

Contributed by Kelly Magliocca, D.D.S., M.P.H.
Desmoplastic fibroma

Desmoplastic fibroma

Positive stains
Negative stains
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