Mandible & maxilla
Benign bone tumors
Desmoplastic fibroma
Author: Nat Pernick, M.D.
Last author update: 1 October 2013
Last staff update: 29 December 2020
Copyright: 2004-2023, PathologyOutlines.com, Inc.
PubMed Search: Desmoplastic fibroma [title]
Table of Contents
Definition / general | Case reports | Treatment | Gross description | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Negative stains | Differential diagnosisCite this page: Pernick N. Desmoplastic fibroma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/mandiblemaxilladesmoplasticfibroma.html. Accessed April 1st, 2023.
Definition / general
- Rare, mean 23 years, range 1 - 75 years
- Intraosseous component of soft tissue fibromatosis
- May be due to local trauma; may be part of Gardner syndrome
- Benign, but up to 35% recur, does not metastasize
Case reports
- 3 year old boy with swelling of the right mandbile (Arch Pathol Lab Med 2002;126:107)
Treatment
- Wide local excision
Gross description
- Firm, rubbery, white, nonencapsulated, fibrous appearing lesion
Microscopic (histologic) description
- Poorly demarcated lesion with interlacing or fascicular pattern of mature fibrous tissue composed of small fibroblasts with no / minimal mitotic activity and abundant collagenous stroma
- No osteoid, no epithelial rests, rare multinucleated giant cells
Microscopic (histologic) images
Contributed by Kelly Magliocca, D.D.S., M.P.H.
Desmoplastic fibroma
Positive stains
