Mandible & maxilla

Osteomyelitis and inflammatory conditions

Peripheral giant cell granuloma

Topic Completed: 1 October 2013

Minor changes: 1 March 2021

Copyright: 2004-2022,, Inc.

PubMed Search: Peripheral giant cell granuloma [title]

Nat Pernick, M.D.
Page views in 2021: 1,855
Page views in 2022 to date: 57
Cite this page: Pernick N. Peripheral giant cell granuloma. website. Accessed January 17th, 2022.
Definition / general
  • Also called giant cell epulis
  • Resembles pyogenic granuloma but may erode alveolar bone or involve periodontal membrane
  • Usually women, mean age 30 years, although may involve children or elderly patients without teeth
  • May be due to trauma, local irritation or chronic infection
  • Recurs if not completely excised
  • Excision with curettage of base of lesion extending into adjacent periodontal membrane
Gross description
  • Inflammatory lesion up to 1.5 cm that protrudes from gingiva at site of chronic inflammation
  • Covered by gingival mucosa or ulcerated
Microscopic (histologic) description
  • Nonencapsulated aggregates of foreign body giant cells and fibroangiomatous stroma with hemorrhage, hemosiderin, acute and chronic inflammatory cells
  • Alveolar bone often expanded in edentulous patients leading to superficial bone loss with peripheral cuffing
Microscopic (histologic) images

Contributed by Kelly Magliocca, D.D.S., M.P.H.
Peripheral giant cell granuloma

Peripheral giant cell granuloma

Differential diagnosis
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