Mandible & maxilla

Malignant odontogenic tumors

Primary intraosseous carcinoma, NOS

Last author update: 1 November 2013
Last staff update: 6 December 2021

Copyright: 2004-2024,, Inc.

PubMed Search: Primary intraosseous carcinoma [title]

Nat Pernick, M.D.
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Cite this page: Pernick N. Primary intraosseous carcinoma, NOS. website. Accessed June 16th, 2024.
Definition / general
  • May arise from epithelial lining of an odontogenic cyst or de novo from intraosseous odontogenic rests
  • Mean age is 52 years (range 4 to 76 years); 70% occur in men (Int J Oral Maxillofac Surg 2001;30:349); most tumors (92%) occur in mandible
  • Progressive swelling of the jaw, pain and loosening of the teeth
  • Cervical nodal metastases are common
  • Aggressive behavior (4 year survival is 40%)
Radiology description
  • Radiolucent cystic-like pattern of bone destruction but with well defined margins
Radiology images

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Lytic and cystic lesion involving right mandible

Case reports
Microscopic (histologic) description
  • Usually squamous cell carcinoma, high grade
Microscopic (histologic) images

Contributed by Kelly Magliocca, D.D.S., M.P.H.
Primary intraosseous carcinoma, NOS

Primary intraosseous carcinoma, NOS

Images hosted on PathOut server:
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Verrucous carcinoma

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Cyst lining with chronic inflammation

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